Haapaniemi T, Nylander G, Sirsjö A, Larsson J, et al.
Plastic and reconstructive surgery. Date of publication 1996 Mar 1;volume 97(3):602-7; discussion 608-9.
1. Plast Reconstr Surg. 1996 Mar;97(3):602-7; discussion 608-9.
Hyperbaric oxygen reduces ischemia-induced skeletal muscle injury.
Haapaniemi T(1), Nylander G, Sirsjö A, Larsson J.
Author information:
(1)Department of Plastic Surgery, Hand Surgery, and Burns, Clinical Research
Center, Faculty of Health Sciences, University Hospital, Linkoping, Sweden.
The effect of hyperbaric oxygen treatment on skeletal muscle submitted to 3 or 4
hours of ischemia was studied in a rat hindlimb model after 48 hours of
reperfusion. Forty-eight male Sprague-Dawley rats were allocated to four groups.
In the two treatment groups, hyperbaric oxygen was given for 45 minutes at 2.2
atm immediately and 4,8,16,24,32, and 40 hours after release of the
ischemia-inducing tourniquet. The injury to skeletal muscle was quantified from
the uptake of 99mtechnetium-pyrophosphate (injected intravenously after 45 hours
of reperfusion) in anterior tibial muscle harvested 3 hours later. The uptake was
significantly lower in hyperbaric oxygen-treated rats than in untreated rats with
3 or 4 hours of ischemia (p < 0.01 and P < 0.05). After 4 hours of ischemia, the
changes in levels of the intracellular muscle compounds adenosine triphosphate,
phosphocreatine, and lactate were less in the hyperbaric oxygen-treated rats than
in the untreated animals.
DOI: 10.1097/00006534-199603000-00017
PMID: 8596792 [Indexed for MEDLINE]
