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Acellular matrix

Acellular matrix

Acellular matrix

OVERVIEW

Acellular Matrices are derived from other than human skin and include the majority of CTPs. All are composed of allogeneic or xenogeneic derived collagen, membrane, or cellular remnants proposed to simulate or exaggerate the characteristics of human skin. All propose to promote healing by the creation of localized intensification of an array of hormonal and enzymatic activity to accelerate closure by migration of native dermal and epithelial components, rather than function as distinctly incorporated tissue closing the skin defect.  [1]


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REFERENCES

  1. Administrators, CGS et al. Local Coverage Determination (LCD) - Wound Application of Cellular and/or Tissue Based Products (CTPs), Lower Extremities (L36690) . 2016;.
Topic 20 Version 1.0

Subtopics

Acell Cytal Burn Matrix is an acellular matrix made of urinary bladder matrix (UBM) for coverage of wounds (second degree burns, partial and full-thickness wounds, etc)

CLINICALIndicationsPartial and full-thickness woundsPressure ulcersVenous ulcersChronic vascular ulcersDiabetic ulcersTrauma wounds: Abrasions, Lacerations, Skin tears Second-degree burnsSurgical wounds: Donor sites/grafts, Post-Mohs' surgery, Post Laser surgery,Podiatric, Wou

ArthroFLEX® is an acellular dermal extracellular matrix for soft tissue repair. See clinical, coding and reimbursement information

The bio-ConneKt® Wound Matrix is an acellular matrix, collagen-based wound dressing for wound coverage. See clinical, coding and reimbursement information.

CLINICALIndicationsAcuteChronicMohs surgeryBurnsTraumaExposed tendon, muscle, boneComplexSurgicalVenous leg ulcersDiabetic ulcersPressure ulcersArterial ulcers

CYMETRA™ MICRONIZED ALLODERM™ is a micronized, particulate form of ALLODERM™ Tissue Matrix. See clinical, coding and reimbursement information

CLINICALIndications (per manufacturer)Partial and full-thickness woundsPressure ulcersVenous ulcersChronic vascular ulcersDiabetic ulcersTrauma wounds: Abrasions, Lacerations, Skin tears Second-degree burnsSurgical wounds: Donor sites/grafts, Post-Mohs' surgery, Post Laser surgery,Podiatric, Wound dehiscence

CLINICALIndications• Chronic vascular ulcers• Diabetic ulcers• Draining wounds• Partial- and full-thickness wounds• Pressure ulcers• Second-degree burns• Surgical wounds (donor sites/grafts, post-Mohs surgery, post-laser surgery, podiatric, wound dehiscence)• Trauma wounds (abrasions, lacerations, skin tears)• Tunneled/undetermined wounds• Venous ulcers

CLINICALIndicationsThe management of wounds including: partial and full-thickness wounds, pressure ulcers, venous ulcers, diabetic ulcers, chronic vascular ulcers, surgical wounds(donor sites/grafts, post-Moh’s surgery, post-laser surgery, podiatric, wound dehiscenc

Integra® BioFix® and Integra® BioFix® Plus are sterile, human tissue allografts, derived from allogeneic dehydrated and decellularized amniotic membrane

CLINICALIndicationsIntegra® BioFix® Flow (BioFix Flow) is a sterile, human tissue allograft, derived from decellularized particulate human placental connective tissue matrix. It is intended for homologous use as a connective tissue matrix. Biofix Flow is provided in a vial.FDAIt is also regulated under PHS 361 [21 CFR 1270 &am

CLINICALIndicationsIntegra® BioFix® and Integra® BioFix® Plus (BioFix) are sterile, human tissue allografts, derived from allogeneic dehydrated and decellularized amniotic membrane. BioFix is intended for homologous use as a wound covering for surgical sites, voids, and tissue defects.FDARegulated under PHS 361 [21 CFR 127

CLINICALIndicationsIntegra template is indicated for the postexcisional treatment of life-threatening full-thickness or deep partial-thickness thermal injuries where sufficient autograft is not available at the time of excision or not desirable due to the physiological condition of the patient. Integra template is also indicated for the repair of sc

CLINICALIndicationsThe management of wounds including: partial and full-thickness wounds, pressure ulcers, venous ulcers, diabetic ulcers, chronic vascular ulcers, tunneled/undermined wounds, surgical wounds (donor sites/grafts, post-Moh’s surgery, post-laser&n

CLINICALIndicationsThe management of wounds including: partial and full-thickness wounds, pressure ulcers, venous ulcers, diabetic ulcers, chronic vascular ulcers, surgical wounds (donor sites/grafts, post-Moh’s surgery, post-laser surgery, podiatric, wound deh

CLINICALIndicationsIntegra dermal regeneration template is indicated for the postexcisional treatment of life-threatening full-thickness or deep partial-thickness thermal injuries where sufficient autograft is not available at the time of excision or not desirable due to the physiological condition of the patient. Integra template is also indicated for the repair of scar contractures when other therapies have failed or when donor sites for re

CLINICALIndicationsIntegra® Omnigraft Dermal Regeneration Matrix is indicated for use in the treatment of partial and full-thickness neuropathic diabetic foot ulcers that are greater than six weeks in duration, with no capsule, tendon or bone exposed, when used in conjunction with standard diabetic ulcer

CLINICALIndicationsPriMatrix® is intended for the management of wounds that include:• Partial and full thickness wounds• Pressure, diabetic, and venous ulcers• Second-degree burns• Surgical wounds—donor sites/grafts, post-Moh’s surgery, post-laser surgery, podiatric,wound dehiscence• Trauma wounds —abrasions, lacerations and skin tears• Tunneled/undermined wounds• Draining wound

CLINICALIndicationsThe management of wounds including: partial and full-thickness wounds, pressure ulcers, venous ulcers, diabetic ulcers, chronic vascular ulcers, tunneled/undermined wounds, surgical wounds (donor sites/grafts, post-Moh’s surgery, post-laser&n

Integra® Wound Matrix (Thin) is a thinner collagen matrix that supports a healing environment for wound management

Interfyl is a matrix comprised of natural human structural and biochemical extracellular matrix components. See clinical, coding and reimbursement information

CLINICALIndicationsKeramatrix® is designed for full and partial thickness wounds with low to high exudate, such as:Venous leg ulcersArterial ulcersDiabetic ulcersPressure ulcersSkin graft donor sitesFirst and second degree burnsSuperficial injuries, cuts, abrasions and surgical woundsFDACleared for marketing under the 510(k) process in January 2009 (K080949), included in FDA product codes FRO (

CLINICALIndications* Partial and full-thickness wounds* Pressure ulcers* Venous ulcers* Chronic vascular ulcers* Diabetic ulcers* Trauma wounds (abrasions, lacerations, second-degree burns, skin tears)* Surgical wounds (donor sites/grafts, post-Mohs surgery, post-laser surgery, podiatric, wounddehiscence). * Draining woundsFDACleared for marketing under the 51

CLINICALIndicationsMicroMatrix® is intended for the management of topical wounds including: partial and full-thickness wounds, pressure ulcers, venous ulcers, diabetic ulcers, chronic vascular ulcers, tunneled/undermined wounds, surgical wounds (donor sites/grafts, post-Mohs surgery, post-laser surgery, podiatric, wound dehiscence), trauma wounds (abrasions, lacerations, second-degree burns, skin tears), and draining wounds. The device is intended for one-time use.

CLINICALIndicationsFor the management of wounds including:Partial and full-thickness woundsPressure ulcersVenous ulcersChronic vascular ulcersDiabetic ulcersTunneled and undermined woundsTrauma wounds (abrasions, lacerations, second-degree burns, skin tears)Drainage wounds and surgical wounds (donor sites/grafts, post-

CLINICALIndicationsFor the management of wounds including:Partial and full-thickness woundsPressure ulcersVenous ulcersChronic vascular ulcersDiabetic ulcersTunneled and undermined woundsTrauma wounds (abrasions, lacerations, second-degree burns, skin tears)Drainage wounds and surgical wounds (donor sites/grafts, post-Mohs surgery, post-laser surgery, podiatric, wound dehiscence)FDA

CLINICALIndicationsFor the management of wounds including:Partial and full-thickness woundsPressure ulcersVenous ulcersChronic vascular ulcersDiabetic ulcersTunneled and undermined woundsTrauma wounds (abrasions, lacerations, second-degree burns, skin tears)Drainage wounds and surgical wounds (donor sites/grafts, post-Mohs surgery, post-laser surgery, podiatric, wound dehiscence)FDA

CLINICALIndications It is indicated “for the management of wounds including: partial and full-thickness wounds; pressure ulcers; venous ulcers; diabetic ulcers; chronic vascular ulcers; tunneled, undermined wounds; surgical wounds (donor sites/grafts, post-Mohs surgery, post-laser surgery, podiatric, wound dehiscence); trauma wounds (abrasions, lacerations, second-degree burns, and skin tears); draining wounds.FDACleared for marketing under the 510(k) pr

CLINICALIndications It is indicated “for the management of wounds including: partial and full-thickness wounds; pressure ulcers; venous ulcers; diabetic ulcers; chronic vascular ulcers; tunneled, undermined wounds; surgical wounds (donor sites/grafts, post-Mohs surgery, post-laser surgery, podiatric, wound dehiscence); trauma wounds (abrasions, lacerations, second-degree burns, and skin tears); draining wounds.FDACleared for marketing under the 510(k) pr

CLINICALIndicationsIntended for the management of wounds and as an effective barrier to resist microbial colonization within the dressing and reduce microbes penetrating through the dressing. FortaDermTM Antimicrobial PHMB Wound Dressing may be used for the management of: partial and full thickness wounds

CLINICALIndicationsIntended for the management of wounds including: partial and full-thickness wounds, venous, diabetic, chronic vascular, and pressure ulcers, tunneled/undermined, surgical, trauma, and draining wounds.