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OASIS® Wound Matrix

OASIS® Wound Matrix

OASIS® Wound Matrix

Technology and Product Assessment
Product Type: Acellular matrix
Other related products
Unbiased information for educational purposes only. WoundReference does not produce, market, advertise, re-sell or distribute healthcare goods or services consumed by, or used on patients. For information about specific products, please contact the manufacturer directly.
OASIS Wound Matrix is an acellular matrix. It is a one-layer structure providing fenestrated, naturally derived ECM. This option offers the shortest time to complete integration.

INTENDED USE: Ideal for supporting wound closure, as part of standard care. Suitable for use with a variety of secondary dressings (applies to all OASIS Matrix Products)
CLAIMED FEATURES: It is an intact matrix naturally derived from porcine small intestinal submucosa (SIS), indicated for the management of wounds.
OPTIONS: Sizes (3 x 3.5 cm fenestrated, 3 x 7 cm fenestrated). 10 Sheets in box.

Manufacturer: Smith & Nephew, Inc.
Information retrieved from manufacturer and/or FDA-approved labels
* Wound Reference does not produce, market, re-sell or distribute health care goods or services consumed by, or used on, patients. The product information contained on this page, including the product images and additional product materials, was collected from various supplier sources. All product claims and specifications are those of the product suppliers. Every effort has been made to ensure the accuracy of the product information, however on occasion manufacturers may alter their products or packaging without notice. Wound Reference assumes no liability for inaccuracies or misstatements about products. The properties of a product may change or be inaccurate following the posting or printing of the product information in the document, either in the print or online version. Due to product changes, information listed in this document is subject to change without notice. We recommend that you always read labels, warnings and instructions for use before using a product. Content on this site is for reference purposes and is not intended to be a substitute for professional advice given by a physician or other licensed healthcare professional.


Oasis Wound Matrix, Per Square Centimeter
Oasis wound matrix, per square centimeter
* Hover on the information button next to each header for detailed explanation on the type of information provided by the table
Select your state for Medicare
DME coverage and co-payment
Patient DME Co-Payment per Billable Unit
DME Reimbursement to Suppliers
Frequency Replacement if Requirements Met
Office and/or Facility - Product reimbursement
Oasis Wound Matrix, Per Square Centimeter
per square centimeter (non-DMEPOS)
See Coding, Coverage and Reimbursement
* Every effort has been made to ensure the accuracy of the product information, however you should visit the manufacturer's website for the latest information.
* Hover on the information button next to each header for detailed explanation on the type of information provided by the table
Recom / Evidence
FDA Safety
Quality Measures
Cost Effectiveness
Oasis Wound Matrix, Per Square Centimeter
Composition: Animal-derived Configuration: Sheet May apply on full-thickness wounds Shelf life: Greater than 2 years Storage: room temp
CPT CodeDescription Physician Reimbursement - Office Physician Reimbursement - Facility Facility Reimbursement
C5271Low cost skin substitute app $534.89
C5273Low cost skin substitute app $1,749.26
C5274Low cost skin substitute app
C5275Low cost skin substitute app $534.89
C5272Low cost skin substitute app
C5276Low cost skin substitute app
C5277Low cost skin substitute app $534.89
C5278Low cost skin substitute app
  • Based on national averages
  • Medicare payments for participating qualified health professionals (QHP) for services performed in their Offices (*) or at a Facility (** i.e., hospital outpatient department or ambulatory service center). Payments are nationally unadjusted average amounts, and do not account for differences in payment due to geographic variation. The allowed rate for non-participating physicians is set at 95% of the allowable for participating physicians. Non-participating physicians are subject to the limiting charge rules. The coinsurance is limited to 20% of the allowable fee.
  • When covered by the Medicare contractor, this manufacturer product is separately payable in a QHP office based on the Average Sales Price (ASP) as reported by the manufacturer on a quarterly basis.
  • Hover on the information button next to each header for detailed explanation on the type of information provided by the table
  • The information provided on this website is informational only. This is not a guarantee of Reimbursement Rates, nor is it intended to make recommendations regarding clinical practices. Information on this website is subject to change with out notice due to changes in reimbursement laws, regulations, rules and policies. The ultimate responsibility for correct coding lies with the provider of services. Please contact the appropriate payer for their interpretation of the appropriate code to use for the procedure.
  • CPT® is a registered trademark of the American Medical Association. All CPT codes and descriptions are copyrighted 2018, American Medical Association. All rights reserved. CPT codes and CPT descriptions are from the current manuals and those included herein are not intended to be all-inclusive and are included for informational purposes only. Codes referenced on Wound Reference are for informational purposes only. Inclusion or exclusion of any codes does not guarantee coverage. Providers should reference the American Medical Association prior to the submission of claims for reimbursement of covered services.
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 It is indicated “for the management of wounds including: partial and full-thickness wounds; pressure ulcers; venous ulcers; diabetic ulcers; chronic vascular ulcers; tunneled, undermined wounds; surgical wounds (donor sites/grafts, post-Mohs surgery, post-laser surgery, podiatric, wound dehiscence); trauma wounds (abrasions, lacerations, second-degree burns, and skin tears); draining wounds.


Cleared for marketing under the 510(k) process in July 2006 (K061711) and is intended for one-time use.” Oasis is included in FDA product code KGN (dressing, wound, collagen)


This device is derived from a porcine source and should not be used in patients with known sensitivity to porcine material. This device is not indicated for use in third degree burns.


• Do not re-sterilize. Discard all open and unused portions of OASIS® Wound Matrix.

• Device is sterile if the package is dry, unopened and undamaged. Do not use if the package seal is broken.

• The device must be used prior to the expiration date.

• Discard device if mishandling has caused possible damage or contamination.

• OASIS® Wound Matrix should not be applied until excessive exudate, bleeding, acute swelling, and infection is controlled.


The following complications are possible. If any of these conditions occur, the device should be removed.

• Infection

• Chronic inflammation (Initial application of wound dressings may be associated with transient, mild, localized inflammation.)

• Allergic reaction

• Excessive redness, pain, swelling, or blistering


This device should be stored in a clean, dry location at room temperature.


This device has been sterilized with ethylene oxide.


NOTE: Always handle OASIS® Wound Matrix using aseptic technique.

I. Wound Bed Preparation

A. Prepare the wound bed using standard methods to ensure it is free of exudate and devitalized tissue. An initial excision or debridement of the wound may be necessary to ensure the wound edges contain viable tissue.

B. Wait for any bleeding to stop before applying OASIS® Wound Matrix.

C. Cleanse the wound thoroughly with sterile saline.

II. Selection and Preparation of OASIS® Wound Matrix

A. Measure the wound and select the appropriate size sheet of dry OASIS® Wound Matrix. If necessary, the product may be additionally fenestrated or meshed with a scalpel.

B. Cut the sheet to a size and shape that will cover the entire wound surface and will extend slightly beyond the wound margins.

III. Application of OASIS® Wound Matrix

A. For ease of handling, apply OASIS® Wound Matrix by placing it in a dry state over the wound.

B. Position the dry OASIS® Wound Matrix to completely contact the entire surface of the wound bed and extend slightly beyond all wound margins. If multiple sheets are necessary to cover the wound, slightly overlap the edges of the sheets.

C. As required, securely anchor OASIS® Wound Matrix with physician’s preferred fixation method (e.g., STERI-STRIPTM, tissue sealant, bolsters, dissolvable clips, sutures, staples, or other appropriate fixation method) based on the type of wound, location of wound, patient’s mobility, and patient compliance.

D. Thoroughly rehydrate OASIS® Wound Matrix by applying sterile saline.

E. To protect OASIS® Wound Matrix from adhering to the secondary dressing, apply an appropriate nonadherent primary wound dressing over the OASIS® Wound Matrix.

F. Apply an appropriate secondary dressing (multi-layer compression bandage system, total contact cast, or other appropriate dressing) that will manage the wound exudate, keep the OASIS® Wound Matrix moist, and keep all layers securely in place.

IV. Dressing Changes

A. To prevent damage to the newly incorporating OASIS® Wound Matrix, only change the primary dressing as necessary, typically every 7 days.

B. Change the secondary dressing as appropriate. Take care to avoid dislodging the OASIS® Wound Matrix when the secondary dressing is changed.

V. Wound Assessment and Wound Bed Preparation for Reapplication of OASIS® Wound Matrix

A. Change all dressings every 7 days, or as necessary.

NOTE: If a gel forms on the wound surface, do not attempt to forcibly remove it. Successful absorption of OASIS® Wound Matrix may form a caramel-colored or off white gel. Do not remove this gel by debridement. This caramelization contains extracellular matrix (ECM), which

continues to replace deficient and missing ECM in the wound.

B. As healing occurs, sections of OASIS® Wound Matrix may gradually peel. Carefully remove any remaining loose products around the edge as needed.

C. Gently cleanse the wound surface with sterile saline; leave the ECM gel intact.

D. Carefully reassess the wound and record healing progression such as wound dimensions, wound depth, wound type, and other relevant information.

VI. Reapplication of OASIS® Wound Matrix and Dressing Changes

A. Change secondary dressings as needed (see step IV).

B. If the wound is free of infection and necrosis but not fully epithelialized, reapply newly prepared OASIS® Wound Matrix over previously absorbed application (see steps II and III).

C. Reapply OASIS® Wound Matrix every 7 days or as needed by repeating previous application steps.

NOTE: If excess exudate collects under the sheet, small openings can be cut in the sheet to allow the exudate to drain.



This section currently focuses primarily on Medicare. It may be expanded in the future to include information on private insurers as well. 

Medicare hospital outpatient prospective payment system (OPPS) cost category assignment:

  • CY 2023: low cost

Frequency of replacement allowed by Medicare:

Medicare Administrative Contractor (MAC) Frequency of replacement if requirements met
Novitas Solutions, Inc. 10 units in 12 weeks
CGS Administrators, LLC 10 units in 12 weeks
First Coast Service Options, Inc. (FCSO)

1 type of product per 12 weeks, fewest repeat applications and amount of product is expected



Wisconsin Physicians Service Insurance Corporation (WPS)

National Government Services, Inc. (NGS)

Carrier discretion

More details on requirements, medical necessity and documentation in specific Medicare Local Coverage Determinations (if available). See section on Coding, Coverage and Reimbursement in topic "Cellular and/or Tissue Products". 

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NOTE: This is a controlled document. This document is not a substitute for proper training, experience, and exercising of professional judgment. While every effort has been made to ensure the accuracy of the contents, neither the authors nor the Wound Reference, Inc. give any guarantee as to the accuracy of the information contained in them nor accept any liability, with respect to loss, damage, injury or expense arising from any such errors or omissions in the contents of the work.
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