Marx RE, Ehler WJ, Tayapongsak P, Pierce LW, et al.
American journal of surgery. Date of publication 1990 Nov 1;volume 160(5):519-24.
1. Am J Surg. 1990 Nov;160(5):519-24. doi: 10.1016/s0002-9610(05)81019-0.
Relationship of oxygen dose to angiogenesis induction in irradiated tissue.
Marx RE(1), Ehler WJ, Tayapongsak P, Pierce LW.
Author information:
(1)Division of Oral and Maxillofacial Surgery, University of Miami School of
Medicine/Jackson Memorial Medical Center, Florida.
Comment in
Am J Surg. 1992 Apr;163(4):457. doi: 10.1016/0002-9610(92)90054-u.
Am J Surg. 1994 May;167(5):551. doi: 10.1016/0002-9610(94)90258-5.
This study was accomplished in an irradiated rabbit model to assess the
angiogenic properties of normobaric oxygen and hyperbaric oxygen as compared
with air-breathing controls. Results indicated that normobaric oxygen had no
angiogenic properties above normal revascularization of irradiated tissue than
did air-breathing controls (p = 0.89). Hyperbaric oxygen demonstrated an eight-
to ninefold increased vascular density over both normobaric oxygen and
air-breathing controls (p = 0.001). Irradiated tissue develops a
hypovascular-hypocellular-hypoxic tissue that does not revascularize
spontaneously. Results failed to demonstrate an angiogenic effect of normobaric
oxygen. It is suggested that oxygen in this sense is a drug requiring hyperbaric
pressures to generate therapeutic effects on chronically hypovascular irradiated
tissue.
DOI: 10.1016/s0002-9610(05)81019-0
PMID: 2240387 [Indexed for MEDLINE]
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