Bainbridge P
Journal of wound care. Date of publication 2013 Aug 1;volume 22(8):407-8, 410-12.
1. J Wound Care. 2013 Aug;22(8):407-8, 410-12.
Wound healing and the role of fibroblasts.
Bainbridge P(1).
Author information:
(1)Cardiff University, UK. pbainbridge@mmm.com
Fibroblasts are critical in supporting normal wound healing, involved in key
processes such as breaking down the fibrin clot, creating new extra cellular
matrix (ECM) and collagen structures to support the other cells associated with
effective wound healing, as well as contracting the wound. This article explores
and summarises the research evidence on the role of fibroblasts, their origins
and activation, and how they navigate the wound bed, as well as how their
activity leads to wound contraction. This article also explores the local
conditions at the wound site, which activate, regulate and ultimately reduce the
fibroblast activity as the skin's integrity returns on healing.
DOI: 10.12968/jowc.2013.22.8.407
PMID: 23924840 [Indexed for MEDLINE]
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