Leng GC, Fowkes FG, et al.
Journal of clinical epidemiology. Date of publication 1992 Oct 1;volume 45(10):1101-9.
1. J Clin Epidemiol. 1992 Oct;45(10):1101-9.
The Edinburgh Claudication Questionnaire: an improved version of the WHO/Rose
Questionnaire for use in epidemiological surveys.
Leng GC(1), Fowkes FG.
Author information:
(1)Wolfson Unit for the Prevention of Peripheral Vascular Diseases, Department of
Public Health Sciences, University of Edinburgh, Scotland.
The WHO/Rose Questionnaire on intermittent claudication was developed in 1962 for
use in epidemiological surveys, and has been widely used. Several population
studies have shown, however, that it is only moderately sensitive (60-68%),
although highly specific (90-100%). In this study, reasons for the poor
sensitivity and good specificity were determined following its application to 586
claudicants and to 61 subjects with other causes of leg pain. The results showed
two important findings: firstly, that over half of the false negatives were
produced by one question alone; and secondly that only three questions were
required to maintain the specificity of the questionnaire. This knowledge, in
conjunction with the pre-testing of additional questions, enabled a new
questionnaire to be constructed: the "Edinburgh Claudication Questionnaire". This
questionnaire was tested on 300 subjects aged over 55 years attending their
general practitioner, and found to be 91.3% (95% CI 88.1-94.5%) sensitive and
99.3% (95% CI 98.9-100%) specific in comparison to the diagnosis of intermittent
claudication made by a physician. The repeatability of the questionnaire after 6
months was excellent (kappa = 0.76, p < 0.001). These results suggest that this
revised version of the WHO/Rose Questionnaire should be adopted for use in future
epidemiological surveys of peripheral vascular disease.
DOI: 10.1016/0895-4356(92)90150-l
PMID: 1474406 [Indexed for MEDLINE]
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