Skyhar MJ, Hargens AR, Strauss MB, Gershuni DH, Hart GB, Akeson WH, et al.
The Journal of bone and joint surgery. American volume. Date of publication 1986 Oct 1;volume 68(8):1218-24.
1. J Bone Joint Surg Am. 1986 Oct;68(8):1218-24.
Hyperbaric oxygen reduces edema and necrosis of skeletal muscle in compartment
syndromes associated with hemorrhagic hypotension.
Skyhar MJ, Hargens AR, Strauss MB, Gershuni DH, Hart GB, Akeson WH.
This study examined the effect of exposures to hyperbaric oxygen on the
development of the edema and necrosis of muscle that are associated with
compartment syndromes that are complicated by hemorrhagic hypotension. A
compartment syndrome (twenty millimeters of mercury for six hours) was induced by
infusion of autologous plasma in the anterolateral compartment of the left hind
limb of seven anesthetized dogs while the mean arterial blood pressure was
maintained at sixty-five millimeters of mercury after 30 per cent loss of blood
volume. These dogs were treated with hyperbaric oxygen (two atmospheres of pure
oxygen) and were compared with six dogs that had an identical compartment
syndrome and hypotensive condition but were not exposed to hyperbaric oxygen.
Forty-eight hours later, edema was quantified by measuring the weights of the
muscles (the pressurized muscle compared with the contralateral muscle), and
necrosis of muscle was evaluated by measuring the uptake of technetium-99m
stannous pyrophosphate. The ratio for edema was significantly (p = 0.01) greater
in dogs that had not been exposed to hyperbaric oxygen (1.15 +/- 0.01) than in
the dogs that had been treated with hyperbaric oxygen (1.01 +/- 0.03), and the
ratio for necrosis of muscle was also significantly (p = 0.04) greater in dogs
that had not had hyperbaric oxygen (1.96 +/- 0.41) than in those that had been
treated with hyperbaric oxygen (1.05 +/- 0.11). Comparisons were also made with
the muscles of four normal control dogs and separately with the muscles of six
normotensive dogs that had an identical compartment syndrome and normal blood
pressure and were not treated with hyperbaric oxygen.(ABSTRACT TRUNCATED AT 250
WORDS)
PMID: 3021776 [Indexed for MEDLINE]
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