Hay CR, Messenger AG, Cotton DW, Bleehen SS, Winfield DA, et al.
Journal of clinical pathology. Date of publication 1987 Apr 1;volume 40(4):387-92.
1. J Clin Pathol. 1987 Apr;40(4):387-92.
Atypical bullous pyoderma gangrenosum associated with myeloid malignancies.
Hay CR, Messenger AG, Cotton DW, Bleehen SS, Winfield DA.
Atypical bullous pyoderma gangrenosum was diagnosed during the course of a
myeloid malignancy in three patients. One patient had chronic myeloid leukaemia,
one acute myeloid leukaemia, and the third, refractory anaemia with excess of
blasts. This atypical form of pyoderma gangrenosum has been specifically
associated with myeloid malignancies. The atypical appearance of the skin lesions
and the clinical context in which they arose caused the true diagnosis to be
delayed in all cases. Treatment with steroids was associated with rapid healing
of the skin lesion. The histopathological changes in the skin biopsy specimens
from these cases were non-specific, and although the histology was considered to
be atypical of pyoderma gangrenosum in one case, the unusual features could be
attributed to the patient's neutropenia. (Skin biopsy was performed to exclude
other specific pathology). Atypical bullous pyoderma gangrenosum is an uncommon
association of the myeloid malignancies. It may remain unrecognised and should be
considered more often.
PMCID: PMC1140969
PMID: 3473088 [Indexed for MEDLINE]
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