Nabeya R, Kobayashi M, Fujita M, Yorifuji K, Eguchi N, Okamoto S, et al.
Nihon Hifuka Gakkai zasshi. The Japanese journal of dermatology. Date of publication 1990 Sep 1;volume 100(10):1029-39.
1. Nihon Hifuka Gakkai Zasshi. 1990 Sep;100(10):1029-39.
[A case of Stewart-Treves syndrome--treatment with recombinant interleukin 2 and
a review of Japanese literature].
[Article in Japanese]
Nabeya R(1), Kobayashi M, Fujita M, Yorifuji K, Eguchi N, Okamoto S.
Author information:
(1)Department of Dermatology, Chiba University School of Medicine.
A 76-year-old woman developed angiosarcoma 11 years after a radical mastectomy in
the chronic lymphedema of the ipsilateral arm, referred to as Stewart-Treves
syndrome. The patient was treated by intravenous and intralesional injection of
recombinant interleukin 2 (rIL-2; TGP-3, Takeda Chemical Industries, LTD, Osaka).
Intralesional injection was more effective than systemic administration. After a
month, the lesion where the local injection was done showed little tumor cells
with a dense infiltrate composed of lymphoid cells. It was observed that NK
activity, LAK activity and IL-2 receptor positive T-cells in the peripheral blood
increased during the administration of rIL-2. As the lesion was too large to be
treated with rIL-2 alone, radiotherapy was performed. But the patient had no
remarkably improvement and died 16 months later from the onset. Immunotherapy
with rIL-2 can be useful for angiosarcoma and more effective regimen of rIL-2 is
a important problem.
PMID: 2266596 [Indexed for MEDLINE]
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