Peyron N, Dandurand M, Guillot B, et al.
Journal des maladies vasculaires. Date of publication 1993 Jan 1;volume 18(4):293-8.
1. J Mal Vasc. 1993;18(4):293-8.
[Malignant tumors as complications of lymphedema].
[Article in French]
Peyron N(1), Dandurand M, Guillot B.
Author information:
(1)Service de Dermatologie, Hôpital Caremeau, CHU de Nîmes.
Malignant tumour arising in chronic congenital or acquired lymphedema is a rare
medical condition. However it must be well known because of the usual severity of
these highly malignant neoplasms. Stewart-Treves angiosarcoma is the most
frequent tumour: it is a vascular malignant tumour, which mostly occur in
post-surgical or radiotherapeutic lymphedema for breast cancer. It differs from
secondary metastasis arising in lymphedema although the clinical and histological
appearance is often very close. Other tumours can grow on this ground: Kaposi's
sarcoma, squamous cell carcinoma, malignant lymphoma, melanoma. On the pathogenic
point of view, many factors converge to this tumoral occurrence: lymphatic stasis
and the reorganization of the conjunctival tissue that it will entail, the local
immunodeficiency, and also systemic factors as a general immunodeficiency or
viral potentially oncogenic infections such as papillomavirus. In practice, the
prevention of lymphedema, the regular monitoring of constituted lymphedemas, the
hygienic and preventive behaviours of infections are the best arrangements to
avoid this tumoral occurrence.
PMID: 8120459 [Indexed for MEDLINE]
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