White LM, Schweitzer ME, Deely DM, Gannon F, et al.
Radiology. Date of publication 1995 Dec 1;volume 197(3):840-2.
1. Radiology. 1995 Dec;197(3):840-2.
Study of osteomyelitis: utility of combined histologic and microbiologic
evaluation of percutaneous biopsy samples.
White LM(1), Schweitzer ME, Deely DM, Gannon F.
Author information:
(1)Department of Radiology, Thomas Jefferson University Hospital, Philadelphia,
PA 19107, USA.
PURPOSE: To determine the utility of combined histologic and microbiologic
evaluation of percutaneous biopsy samples in cases of suspected osteomyelitis.
MATERIALS AND METHODS: Twenty-five patients with suspected osteomyelitis were
prospectively studied over a 1-year period. With usual trephine techniques under
radiologic guidance, core and aspiration biopsy samples were obtained in each
patient for both histologic and microbiologic analyses.
RESULTS: Sixteen biopsy specimens demonstrated histologic evidence of
osteomyelitis. Of these, eight were also culture positive. Seven of the eight
culture-negative, histologically positive cases were interpreted as chronic
osteomyelitis. In no patient were cultures positive and histologic findings
negative. Three of 19 patients with proved osteomyelitis had negative histologic
and microbiologic findings. The sensitivity of culture in the diagnosis of
osteomyelitis in our study was 42%; the sensitivity of both culture and
histologic findings was 84%.
CONCLUSION: Although the volume of a biopsy specimen is a major determinant of
culture yield, a portion of a percutaneous biopsy sample should be histologically
evaluated for possible osteomyelitis.
DOI: 10.1148/radiology.197.3.7480765
PMID: 7480765 [Indexed for MEDLINE]
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