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Is it possible that Dakins, with a pH of 9-10, can really be noncytotoxic?
Jul 12, 2024 by Kathryn Erickson, RN, BSN, PHN MBA, CWCN
2 replies
Elaine Horibe Song
MD, PhD, MBA

Hi Kathryn, 

Thank you for your question. This previous Curbside Consult provides a quick background on Dakin's solution: https://woundreference.com/app/post?id=1023

In a nutshell, dilution matters: At the appropriate dilution (0.125% to 0.5%), Dakin's solution can effectively cleanse wounds without causing significant harm to viable tissues. The lower the concentration, the less likely it is to be cytotoxic. 

For management of infected and/or non-healing wounds, Dakin’s solution, modified at a concentration of ten-fold dilution or less (NaOCl 0.025% or less) has been shown to maintain its bactericidal and fungicidal properties without significantly adversely affecting the normal healing process. [1]

So while the pH of Dakin's solution suggests potential cytotoxicity, its actual effect depends on the concentration used and the clinical context (e.g. wound type, patient health status, and other treatments being used).

Hope this helps!

[1] UENO https://pubmed.ncbi.nlm.nih.gov/30173720/

Jul 16, 2024
Kathryn Erickson
RN, BSN, PHN MBA, CWCN
Yes, thank you!
Jul 16, 2024
* Information provided without clinical evaluation and is not intended as a replacement for in-person consultation with a medical professional. The information provided through Curbside Consult is not a substitute for proper training, experience, and exercising of professional judgment. While every effort has been made to ensure the accuracy of the contents, neither the authors nor the Wound Reference, Inc. give any guarantee as to the accuracy of the information contained in them nor accept any liability, with respect to loss, damage, injury or expense arising from any such errors or omissions in the contents of the work.
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