Jia Y, Han N, Guo H, Li H, Du Y, Li C, Li J, et al.
European journal of medical research. Date of publication 2025 Feb 22;volume 30(1):125.
1. Eur J Med Res. 2025 Feb 22;30(1):125. doi: 10.1186/s40001-025-02387-9.
Hyperbaric oxygen therapy for acute carbon monoxide poisoning patients with coma
onset.
Jia Y(1), Han N(2), Guo H(1), Li H(1), Du Y(1), Li C(1), Li J(3).
Author information:
(1)Department of Emergency Medicine, Hebei General Hospital, No. 348, Heping
West Road, Xinhua District, Shijiazhuang City, 050051, Hebei Province, China.
(2)Department of Neurointervention, Hebei General Hospital, Shijiazhuang,
050051, China.
(3)Department of Emergency Medicine, Hebei General Hospital, No. 348, Heping
West Road, Xinhua District, Shijiazhuang City, 050051, Hebei Province, China.
18633012328@163.com.
OBJECTIVE: This study aimed to evaluate the effects of coma on the prognosis and
delayed encephalopathy in patients with acute carbon monoxide poisoning (DEACMP)
and to analyze the predictive factors affecting the prognosis of these patients.
METHODS: Patients with acute carbon monoxide poisoning were divided into
comatose and non-comatose groups. The primary outcomes included clinical cure
and the occurrence of DEACMP. Multivariate logistic regression analysis was
performed to identify independent predictors of clinical outcome.
RESULTS: Multivariate analysis indicated that coma (clinical cure: adjusted odds
ratio [aOR] 0.24, 95% CI 0.12-0.47; DEACMP: aOR 42.5, 95% CI 7.99-789), longer
the time from onset to the first HBOT (clinical cure: aOR 0.43, 95% CI
0.24-0.77; DEACMP: aOR 3.21, 95% CI 1.56-6.78) and abnormal chest CT findings
(clinical cure: aOR 0.23, 95% CI 0.12-0.45; DEACMP: aOR 5.36, 95% CI 2.41-12.60)
were associated with a lower rate of clinical cure and a higher proportion of
DEACMP; and lower age was an independent predictor of clinical cure (aOR 0.96,
95% CI 0.94-0.98), but not of DEACMP (aOR 0.99, 95% CI 0.96-1.01). In comatose
patients, both the duration of coma and abnormal chest CT findings were an
independent factor for clinial cure (aOR 0.96, 95% CI 0.93-0.99; aOR 0.34, 95%
CI 0.15-0.74) and DEACMP (aOR 1.09, 95% CI 1.06-1.14; aOR 4.93, 95% CI
1.67-16.30).
CONCLUSION: Coma and the duration of coma were significant predictors of
clinical cure and DEACMP in patients; the older the patient, the longer the
duration of coma, and the longer the time from onset to the first hyperbaric
oxygen therapy (> 6 h), indicating that the patient's prognosis is often worse;
abnormal chest CT manifestations were also an independent risk factor for a poor
patient's prognosis.
© 2025. The Author(s).
DOI: 10.1186/s40001-025-02387-9
PMCID: PMC11847349
PMID: 39987100 [Indexed for MEDLINE]
Conflict of interest statement: Declarations. Competing interests: The authors
declare no competing interests.
