Shealy FG Jr, DeLoach ED, et al.
Advances in skin & wound care. Date of publication 2006 Jul 1;volume 19(6):310-22.
1. Adv Skin Wound Care. 2006 Jul-Aug;19(6):310-22. doi:
10.1097/00129334-200607000-00010.
Experience with the use of apligraf to heal complicated surgical and nonsurgical
wounds in a private practice setting.
Shealy FG Jr(1), DeLoach ED.
Author information:
(1)Shealy Surgical Center, PA, Hendersonville, NC, USA.
Apligraf is supplied as a ready-to-use living fibroblast and keratinocyte
bilayer in culture. This therapy has been shown to facilitate healing of venous
ulcers and diabetic foot ulcers. Several case reports suggest that Apligraf may
also be effective in healing acute excisional wounds and complicated surgical
defects. Apligraf can, in appropriate settings, be used as an alternative to
autografts, avoiding the morbidity of donor site wounds. The present case review
summarizes outcomes in 16 patients with 18 complicated surgical and nonsurgical
wounds treated with Apligraf, which was meshed or fenestrated as needed to
obtain better wound coverage and to allow drainage. Of 16 patients, 15 (94%)
experienced complete healing (16 of 18 wounds; 89%). Both surgical and
nonsurgical wounds responded well, with healing times ranging from 21 to 550
days. Patients generally stated that they were satisfied with their degree of
healing and with the opportunity to avoid the surgical procedures associated
with autograft donor sites.
DOI: 10.1097/00129334-200607000-00010
PMID: 16885645 [Indexed for MEDLINE]
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