Mortimer PS, Rockson SG, et al.
The Journal of clinical investigation. Date of publication 2014 Mar 1;volume 124(3):915-21.
1. J Clin Invest. 2014 Mar;124(3):915-21. doi: 10.1172/JCI71608. Epub 2014 Mar 3.
New developments in clinical aspects of lymphatic disease.
Mortimer PS, Rockson SG.
The lymphatic system is fundamentally important to cardiovascular disease,
infection and immunity, cancer, and probably obesity--the four major challenges
in healthcare in the 21st century. This Review will consider the manner in which
new knowledge of lymphatic genes and molecular mechanisms has demonstrated that
lymphatic dysfunction should no longer be considered a passive bystander in
disease but rather an active player in many pathological processes and,
therefore, a genuine target for future therapeutic developments. The specific
roles of the lymphatic system in edema, genetic aspects of primary lymphedema,
infection (cellulitis/erysipelas), Crohn's disease, obesity, cancer, and
cancer-related lymphedema are highlighted.
DOI: 10.1172/JCI71608
PMCID: PMC3938261
PMID: 24590276 [Indexed for MEDLINE]
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