Short WD, Wang X, Keswani SG, et al.
Advances in wound care. Date of publication 2022 Mar 1;volume 11(3):121-131.
1. Adv Wound Care (New Rochelle). 2022 Mar;11(3):121-131. doi:
10.1089/wound.2021.0059. Epub 2021 Aug 27.
The Role of T Lymphocytes in Cutaneous Scarring.
Short WD(1)(2), Wang X(1)(2), Keswani SG(1)(2).
Author information:
(1)Department of Surgery, Baylor College of Medicine, Houston, Texas, USA.
(2)Laboratory for Regenerative Tissue Repair, Texas Children's Hospital, Houston,
Texas, USA.
Significance: Cutaneous scarring affects millions of patients worldwide and
results in significant financial and psychosocial burdens. Given the immune
system's intricate involvement in the initiation and progression of wound
healing, it is no surprise that the scarring outcome can be affected by the
actions of various immune cells and the cytokines and growth factors they
produce. Understanding the role of T cells in regulating immune responses and
directing the action of wound mesenchymal cells is essential to developing
antifibrotic therapies to reduce the burden of scarring. Recent Advances: As the
immune system is intimately involved in wound healing, much work has examined the
impact of T cells and their cytokines on the final wound outcome. New innovative
tools for studying T cells have resulted in more sophisticated immunophenotyping
capabilities and the ability to examine effects of individual cytokines in the
wound environment. Critical Issues: Despite continued advances in the study of
specific immune cells and their effects on dermal fibrosis, minimal progress has
been made to modulate immune responses to result in improved wound cosmesis.
Future Directions: The actions of T cells represent potential pharmacologic
targets that could lead to novel bioengineered or immunoengineered therapies to
improve the lives of people with cutaneous scarring.
DOI: 10.1089/wound.2021.0059
PMCID: PMC8742284
PMID: 34238032 [Indexed for MEDLINE]
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