Thomsen K, Rothenborg HW, et al.
Archives of dermatology. Date of publication 1979 Jul 1;volume 115(7):851-2.
1. Arch Dermatol. 1979 Jul;115(7):851-2.
Clofazimine in the treatment of pyoderma gangrenosum.
Thomsen K, Rothenborg HW.
Ten patients with pyoderma gangrenosum, seven female and three male, 25 to 94
years old, mainly with multiple lesions, have been treated with clofazimine, 100
mg three times daily. Associated disease was registered in three patients:
diabetes mellitus, a previous adenocarcinoma of the colon treated by
hemicolectomy, and pustulosis palmoplantaris. In a further patient, M-component
was found in the serum. In seven cases the lesions were completely healed by two
to five months of therapy, and in three cases the ulcers healed partially. Side
effects were redness of the skin in seven cases and dryness of the skin in two
patients. No hematological side effects occurred. The working mechanism is still
obscure.
PMID: 453894 [Indexed for MEDLINE]
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