Fuller FW
Journal of burn care & research : official publication of the American Burn Association. Date of publication 2009 May 1;volume 30(3):464-70.
1. J Burn Care Res. 2009 May-Jun;30(3):464-70. doi: 10.1097/BCR.0b013e3181a28c9b.
The side effects of silver sulfadiazine.
Fuller FW(1).
Author information:
(1)Burn Center, Saint Barnabas Medical Center, Livingston, New Jersey, USA.
Silver sulfadiazine cream has an enviable safety record in burn treatment.
However, it side effects, exemplified by allergic reactions to its sulfadiazine
moiety, silver staining of the treated burn wound, hyperosmolality,
methemoglobinemia, and hemolysis due to a congential lack of glucose-6-phospate
dehydrogenase, may be missed or misinterpreted. Early post burn leukopenia, once
thought to be a side effect of the use of silver sulfadiazine in burn wound
therapy, is no longer regarded as such since it has been found to occur with the
use of other burn topical agents. Its presence is no longer an indication to
discontinue silver sulfadiazine burn wound therapy. Because these side effects
are uncommon, any one physician or burn facility usually has limited experience
in diagnosing and treating them.
DOI: 10.1097/BCR.0b013e3181a28c9b
PMID: 19349889 [Indexed for MEDLINE]
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