Marcus B
Journal of wound care. Date of publication 2016 Oct 1;volume 25(Sup10):S18-S24.
1. J Wound Care. 2016 Oct 1;25(Sup10):S18-S24. doi: 10.12968/jowc.2016.25.Sup10.S18.
Treatment of large, complex, non-healing wounds with cryopreserved amniotic
suspension allograft: a case series.
Marcus B(1).
Author information:
(1)North Fulton Hospital Hyperbaric and Wound Care Center, 517 Johnson Ferry
Road, NE, Atlanta, GA 30328.
OBJECTIVE: Cryopreserved amniotic suspension allograft (CASA) is a regenerative
tissue suspension containing amniotic membrane and amniotic fluid components used
for soft-tissue repair, replacement, and reconstruction. The aim of this case
series is to examine its effects in different wound types.
METHOD: In a retrospective series CASA was applied to chronic non-healing wounds.
All patients were treated at a single center between June 2013 and December 2014.
The criterion for application of CASA was lack of progress toward wound healing
despite standard treatments and adjuvant therapies.
RESULTS: We assessed five patients aged between 39 to 86 years old. Three
patients had surgical/radiation wounds, one had a sacral pressure ulcer, and one
had a diabetic foot ulcer (DFU). All patients experienced progressive improvement
in wound area and volume during treatment with CASA. One patient (postmastectomy
tissue necrosis) required surgical closure in conjunction with removal of
retained sutures. CASA applied topically and subcutaneously was particularly well
suited to application in these wounds with large sinus tracts or undermining. All
five patients experienced complete wound closure following one to two
applications of CASA over 5 to 22 weeks.
CONCLUSION: This series highlights the effective use of CASA in recalcitrant
large soft-tissue wounds, DFUs, and deep wounds with tendon exposure.
DECLARATION OF INTEREST: This study was supported by a grant from Derma Sciences
(Princeton, NJ, US).
DOI: 10.12968/jowc.2016.25.Sup10.S18
PMID: 27681806
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