Aygenc E, Celikkanat S, Kaymakci M, Aksaray F, Ozdem C, et al.
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-.... Date of publication 2004 Mar 1;volume 130(3):351-6.
1. Otolaryngol Head Neck Surg. 2004 Mar;130(3):351-6.
Prophylactic effect of pentoxifylline on radiotherapy complications: a clinical
study.
Aygenc E(1), Celikkanat S, Kaymakci M, Aksaray F, Ozdem C.
Author information:
(1)Department of Otorhinolaryngology-Head and Neck Surgery, Department of Numune
Research and Educational Hospital, Ankara, Turkey. eaygenc@turk.net
OBJECTIVE: The purpose of this study was to assess the prophylactic effect of
pentoxifylline (Ptx) on complications related to radiation.
STUDY DESIGN AND SETTING: Seventy-eight patients who had postoperative
radiotherapy for squamous cell carcinoma of the head and neck were enrolled into
a prospective study. Patients were randomly assigned to the Ptx group (40
patients) and the control group (38 patients). Ptx was given to the patients at a
dose of 400 mg 3 times a day orally to a total of 1200 mg. We noted radiotherapy
complications in each group.
RESULTS: Four patients were not able to tolerate this drug due to the development
of gastrointestinal symptoms and dizziness. Late skin changes, fibrosis, and soft
tissue necrosis were more severely in the control group than in the Ptx group (P
< 0.05). We could find no positive effects on acute skin reactions and pain (P >
0.05).
CONCLUSION: Our study suggests that Ptx has a prophylactic effect on the
radiation complications. This can be explained by protective effect of Ptx
against vascular pathology.
DOI: 10.1016/j.otohns.2003.08.015
PMID: 15054378 [Indexed for MEDLINE]
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