Kolimi P, Narala S, Nyavanandi D, Youssef AAA, Dudhipala N, et al.
Cells. Date of publication 2022 Aug 6;volume 11(15):.
1. Cells. 2022 Aug 6;11(15):2439. doi: 10.3390/cells11152439.
Innovative Treatment Strategies to Accelerate Wound Healing: Trajectory and
Recent Advancements.
Kolimi P(1), Narala S(1), Nyavanandi D(1), Youssef AAA(1)(2), Dudhipala N(1).
Author information:
(1)Department of Pharmaceutics and Drug Delivery, School of Pharmacy, University
of Mississippi, Oxford, MS 38677, USA.
(2)Department of Pharmaceutical Technology, Faculty of Pharmacy, Kafrelsheikh
University, Kafrelsheikh 33516, Egypt.
Wound healing is highly specialized dynamic multiple phase process for the
repair of damaged/injured tissues through an intricate mechanism. Any failure in
the normal wound healing process results in abnormal scar formation, and chronic
state which is more susceptible to infections. Chronic wounds affect patients'
quality of life along with increased morbidity and mortality and are huge
financial burden to healthcare systems worldwide, and thus requires specialized
biomedical intensive treatment for its management. The clinical assessment and
management of chronic wounds remains challenging despite the development of
various therapeutic regimens owing to its painstakingly long-term treatment
requirement and complex wound healing mechanism. Various conventional approaches
such as cell therapy, gene therapy, growth factor delivery, wound dressings, and
skin grafts etc., are being utilized for promoting wound healing in different
types of wounds. However, all these abovementioned therapies are not
satisfactory for all wound types, therefore, there is an urgent demand for the
development of competitive therapies. Therefore, there is a pertinent
requirement to develop newer and innovative treatment modalities for multipart
therapeutic regimens for chronic wounds. Recent developments in advanced wound
care technology includes nanotherapeutics, stem cells therapy, bioengineered
skin grafts, and 3D bioprinting-based strategies for improving therapeutic
outcomes with a focus on skin regeneration with minimal side effects. The main
objective of this review is to provide an updated overview of progress in
therapeutic options in chronic wounds healing and management over the years
using next generation innovative approaches. Herein, we have discussed the skin
function and anatomy, wounds and wound healing processes, followed by
conventional treatment modalities for wound healing and skin regeneration.
Furthermore, various emerging and innovative strategies for promoting quality
wound healing such as nanotherapeutics, stem cells therapy, 3D bioprinted skin,
extracellular matrix-based approaches, platelet-rich plasma-based approaches,
and cold plasma treatment therapy have been discussed with their benefits and
shortcomings. Finally, challenges of these innovative strategies are reviewed
with a note on future prospects.
DOI: 10.3390/cells11152439
PMCID: PMC9367945
PMID: 35954282 [Indexed for MEDLINE]
Conflict of interest statement: The authors declare no conflict of interest.
