Di Mitri M, Di Carmine A, Thomas E, Iacobacci G, Collautti E, D'Antonio S, Libri M, Gargano T, Lima M, et al.
Plastic and reconstructive surgery. Global open. Date of publication 2023 Sep 14;volume 11(9):e5244.
1. Plast Reconstr Surg Glob Open. 2023 Sep 14;11(9):e5244. doi:
10.1097/GOX.0000000000005244. eCollection 2023 Sep.
Fish Skin Graft: Narrative Review and First Application for Abdominal Wall
Dehiscence in Children.
Di Mitri M(1), Di Carmine A(1), Thomas E(1), Iacobacci G(2), Collautti E(1),
D'Antonio S(1), Libri M(1), Gargano T(1), Lima M(1).
Author information:
(1)From Pediatric Surgery Department, IRCCS Azienda Ospedaliero-Universitaria di
Bologna, Bologna, Italy.
(2)Sviluppo Professionale e Implementazione della Ricerca nelle Professioni
Sanitarie, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
Acellular fish skin grafts (FSGs) are tissue-based products created by minimally
processing the skin of the Atlantic cod (Gadus morhua). The FSG is rich in
omega-3 and facilitates tissue regeneration by supporting revascularization and
ingrowth in the proliferation and remodeling phases of wound healing. FSG is
structurally more similar to human skin than antiviral-processed skin
substitutes such as amniotic membrane, and there are no known prion, bacterial,
or viral diseases that can be transmitted from North-Atlantic cod to humans. The
FSG is processed using a proprietary method that preserves the structure and
lipid composition of the skin. FSG is CE marked, and US Food and Drug
Administration cleared for multiple clinical applications in partial and
full-thickness wounds. FSG is currently the only acellular dermal matrix product
that does not originate from mammalian tissues. For this narrative review,
Medline and UpToDate were used to include a total of 21 articles published from
2015 to 2022 about fish skin graft use. We also reported a case of a 7-year-old
boy who underwent treatment with FSG for abdominal wall dehiscence at our
department of pediatric surgery, IRCCS Sant'Orsola-Malpighi, Alma Mater
Studiorum, University of Bologna, University Hospital of Bologna. FSG provides a
valuable and sustainable treatment that improves wound healing in both adult and
pediatric populations. We described the first application of an FSG for wound
dehiscence of the abdominal wall in a pediatric patient, reporting how FSG was
completely reabsorbed and improved the skin's repair.
Copyright © 2023 The Authors. Published by Wolters Kluwer Health, Inc. on behalf
of The American Society of Plastic Surgeons.
DOI: 10.1097/GOX.0000000000005244
PMCID: PMC10501472
PMID: 37718992
Conflict of interest statement: The authors have no financial interest to
declare in relation to the content of this article.
