Mrugala A, Sui A, Plummer M, Altman I, Papineau E, Frandsen D, Hill D, Ennis WJ, et al.
International wound journal. Date of publication 2016 Aug 1;volume 13(4):485-92.
1. Int Wound J. 2016 Aug;13(4):485-92. doi: 10.1111/iwj.12458. Epub 2015 May 14.
Amniotic membrane is a potential regenerative option for chronic non-healing
wounds: a report of five cases receiving dehydrated human amnion/chorion
membrane allograft.
Mrugala A(1), Sui A(2)(3), Plummer M(3), Altman I(3), Papineau E(3), Frandsen
D(3)(4), Hill D(3), Ennis WJ(3).
Author information:
(1)Saint Louis University School of Medicine, St. Louis, MO, USA.
(2)Chicago College Osteopathic Medicine, Midwestern University, Downers Grove,
IL, USA.
(3)Division of Vascular Surgery, Section of Wound Healing and Tissue Repair,
University of Illinois Hospital and Health Sciences System, Chicago, IL, USA.
(4)Department of Wound Healing, Grand View Hospital, Sellersville, PA, USA.
A case series of five patients with a total of six chronic non-healing wounds
(>30 day duration) were non-randomly selected to evaluate the performance,
safety and handling properties of dehydrated human amnion/chorion membrane
allograft, an amniotic membrane scaffolding product. The patients had lower
extremity wounds that had previously failed standard of care within a university
outpatient/inpatient wound healing programme. Five wounds treated with
dehydrated amnion/chorion membrane allograft showed a mean 43% area reduction
from baseline (51% median) at 3 weeks into treatment and completely healed with
a 64-day median time to closure (SD ±27·6 days). One wound worsened at 3 weeks
and was found to have a complete central vein obstruction that was treated with
long-term mild compression but still eventually healed at 6 months. Removing
this outlier, the four responding wounds had a 72% mean and 69% median change in
area from baseline, at the 3 week point. All five patients received only one
application of dehydrated human amnion/chorion membrane allograft, and there
were no adverse events. The product was easy to use, administer and handle. In
summary, dehydrated human amnion/chorion membrane allograft appears to be a
safe, effective and easy to use therapy for chronic non-healing wounds. This
study describes the details of these clinical cases and provides an overview of
the current evidence on the use of amniotic tissue in clinical practice.
© 2015 The Authors. International Wound Journal published by
Medicalhelplines.com Inc and John Wiley & Sons Ltd.
DOI: 10.1111/iwj.12458
PMCID: PMC7950060
PMID: 25974156 [Indexed for MEDLINE]
