Boyar V
Journal of wound, ostomy, and continence nursing : official publication of The Wound, Ostomy an.... Date of publication 2016 Sep 1;volume 43(5):547-50.
1. J Wound Ostomy Continence Nurs. 2016 Sep-Oct;43(5):547-50. doi:
10.1097/WON.0000000000000266.
Efficacy of Dialkylcarbamoylchloride-Coated Dressing in Management of Colonized
or Infected Neonatal and Pediatric Wounds.
Boyar V(1).
Author information:
(1)Vita Boyar, MD, Division of Neonatal-Perinatal Medicine, Department of
Pediatrics, Cohen Children's Medical Center of New York, New Hyde Park, New
York; and Hofstra North Shore-LIJ School of Medicine, Hempstead, New York.
BACKGROUND: Wound healing is a dynamic process that normally follows a
predictable cascade of events. A common cause of delayed wound healing or wound
dehiscence is increased colonization with microbes, often leading to infection.
Infection may impede the healing process by inducing an undesirable inflammatory
response. Systemic antibiotics and topical antiseptics are mainstays of
treatment, but their adverse side effects and the potential for emergence of
resistant microbial strains have led to a search for alternative approaches for
control of bioburden.
CASES: We describe two neonates and one 10-year-old girl who experienced delayed
wound healing treated with a nonmedicated dressing that exploits bacterial
cell-surface hydrophobic interactions via a dressing with a fatty acid
(dialkylcarbamoylchloride [DACC]) coating. This dressing was used in a
colonized, unstageable occipital pressure injuries, an infected stage 4 pressure
injury over a vertebra, and a dehisced surgical sternal wound. Complete closure
was achieved in all wounds within 2 to 4 weeks.
CONCLUSION: We employed a DACC-coated dressing that provides bacteriostatic
activity without creating cytotoxicity or an inflammatory response.
DOI: 10.1097/WON.0000000000000266
PMID: 27607752 [Indexed for MEDLINE]
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