Baitule S, Patel AH, Murthy N, Sankar S, Kyrou I, Ali A, Randeva HS, Robbins T, et al.
Medicina (Kaunas, Lithuania). Date of publication 2021 Oct 19;volume 57(10):.
1. Medicina (Kaunas). 2021 Oct 19;57(10):1134. doi: 10.3390/medicina57101134.
A Systematic Review to Assess the Impact of Hyperbaric Oxygen Therapy on
Glycaemia in People with Diabetes Mellitus.
Baitule S(1), Patel AH(1)(2), Murthy N(1)(2), Sankar S(1)(2), Kyrou
I(1)(2)(3)(4), Ali A(1)(2), Randeva HS(1)(2), Robbins T(1)(2)(3)(5).
Author information:
(1)Warwickshire Institute for the Study of Diabetes, Endocrinology & Metabolism,
University Hospitals Coventry & Warwickshire NHS Trust, Clifford Bridge Road,
Coventry CV2 2DX, UK.
(2)Warwick Medical School, Faculty of Science, Engineering and Medicine,
University of Warwick, Coventry CV4 7AL, UK.
(3)Faculty of Health & Life Sciences, Coventry University, Coventry CV1 5FB, UK.
(4)Aston Medical School, College of Health and Life Sciences, Aston University,
Birmingham B4 7ET, UK.
(5)Institute of Digital Healthcare, WMG, University of Warwick, Coventry CV4
7AL, UK.
Background and Objectives: Hyperbaric oxygen is a recognised treatment for a
range of medical conditions, including treatment of diabetic foot disease. A
number of studies have reported an impact of hyperbaric oxygen treatment on
glycaemic control in patients undergoing treatment for diabetic foot disease.
There has been no systematic review considering the impact of hyperbaric oxygen
on glycaemia in people with diabetes. Materials and Methods: A prospectively
PROSPERO-registered (PROSPERO registration: CRD42021255528) systematic review of
eligible studies published in English in the PUBMED, MEDLINE, and EMBASE
databases, based on the following search terms: hyperbaric oxygen therapy, HBO2,
hyperbaric oxygenation, glycaemic control, diabetes, diabetes Mellitus,
diabetic, HbA1c. Data extraction to pre-determined piloted data collection form,
with individual assessment of bias. Results: In total, 10 eligible publications
were identified after screening. Of these, six articles reported a statistically
significant reduction in blood glucose from hyperbaric oxygen treatment, while
two articles reported a statistically significant increase in peripheral insulin
sensitivity. Two articles also identified a statistically significant reduction
in HbA1c following hyperbaric oxygen treatment. Conclusions: There is emerging
evidence suggesting a reduction in glycaemia following hyperbaric oxygen
treatment in patients with diabetes mellitus, but the existing studies are in
relatively small cohorts and potentially underpowered. Additional large
prospective clinical trials are required to understand the precise impact of
hyperbaric oxygen treatment on glycaemia for people with diabetes mellitus.
DOI: 10.3390/medicina57101134
PMCID: PMC8541526
PMID: 34684171 [Indexed for MEDLINE]
Conflict of interest statement: The authors declare no conflict of interest.
