Kennel KA, Drake MT, Hurley DL, et al.
Mayo Clinic proceedings. Date of publication 2010 Aug 1;volume 85(8):752-7; quiz 757-8.
1. Mayo Clin Proc. 2010 Aug;85(8):752-7; quiz 757-8. doi: 10.4065/mcp.2010.0138.
Vitamin D deficiency in adults: when to test and how to treat.
Kennel KA(1), Drake MT, Hurley DL.
Author information:
(1)Division of Endocrinology, Mayo Clinic, Rochester, MN 55905, USA.
hurley.daniel@mayo.edu
Recent evidence for the nonskeletal effects of vitamin D, coupled with
recognition that vitamin D deficiency is common, has revived interest in this
hormone. Vitamin D is produced by skin exposed to ultraviolet B radiation or
obtained from dietary sources, including supplements. Persons commonly at risk
for vitamin D deficiency include those with inadequate sun exposure, limited oral
intake, or impaired intestinal absorption. Vitamin D adequacy is best determined
by measurement of the 25-hydroxyvitamin D concentration in the blood. Average
daily vitamin D intake in the population at large and current dietary reference
intake values are often inadequate to maintain optimal vitamin D levels.
Clinicians may recommend supplementation but be unsure how to choose the optimal
dose and type of vitamin D and how to use testing to monitor therapy. This review
outlines strategies to prevent, diagnose, and treat vitamin D deficiency in
adults.
DOI: 10.4065/mcp.2010.0138
PMCID: PMC2912737
PMID: 20675513 [Indexed for MEDLINE]
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