Ruocco E, Sangiuliano S, Gravina AG, Miranda A, Nicoletti G, et al.
Journal of the European Academy of Dermatology and Venereology : JEADV. Date of publication 2009 Sep 1;volume 23(9):1008-17.
1. J Eur Acad Dermatol Venereol. 2009 Sep;23(9):1008-17. doi:
10.1111/j.1468-3083.2009.03199.x. Epub 2009 Mar 11.
Pyoderma gangrenosum: an updated review.
Ruocco E(1), Sangiuliano S, Gravina AG, Miranda A, Nicoletti G.
Author information:
(1)Department of Dermatology, Second University of Naples, Naples, Italy.
Pyoderma gangrenosum is a rare, ulcerative, cutaneous condition. First described
in 1930, the pathogenesis of pyoderma gangrenosum remains unknown, but it is
probably related to a hyperergic reaction. There are various clinical and
histological variants of this disorder. Pyoderma gangrenosum often occurs in
association with a systemic disease such as inflammatory bowel disease,
rheumatologic disease, paraproteinaemia, or haematological malignancy. The
diagnosis, mainly based on the clinical presentation and course, is confirmed
through a process of elimination of other causes of cutaneous ulcers. Local
treatment may be sufficient for mild disease, while for severe cases, systemic
immunosuppressants are the mainstay. Long-term treatment with these agents is
often required, but this can expose patients to adverse side-effects.
DOI: 10.1111/j.1468-3083.2009.03199.x
PMID: 19470075 [Indexed for MEDLINE]
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