Papanas N, Maltezos E, et al.
The international journal of lower extremity wounds. Date of publication 2007 Mar 1;volume 6(1):37-53.
1. Int J Low Extrem Wounds. 2007 Mar;6(1):37-53.
Growth factors in the treatment of diabetic foot ulcers: new technologies, any
promises?
Papanas N(1), Maltezos E.
Author information:
(1)Outpatient Department of Diabetes, Obesity and Metabolism at the Second
Department of Internal Medicine, Democritus University of Thrace, Greece.
papanasnikos@yahoo.gr
Foot ulcers remain a common problem, leading to increased morbidity in patients
with diabetes. Despite the progress that has been achieved in revascularization
techniques as well as in off-loading to relieve high-pressure areas, diabetic
foot wounds remain a clinical challenge. Growth factors are a major technological
advance that promised to change the face of wound healing. The most important of
growth factors are recombinant human platelet-derived growth factor-BB and
granulocyte colony-stimulating factor. The former has been approved by the FDA
for the treatment of neuropathic ulcers when there is adequate blood supply. The
latter is less demonstrably useful. Advances include methods of delivering growth
factors.
DOI: 10.1177/1534734606298416
PMID: 17344201 [Indexed for MEDLINE]
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