Romanelli M, Dini V, Bertone MS, et al.
Advances in skin & wound care. Date of publication 2010 Jan 1;volume 23(1):34-8.
1. Adv Skin Wound Care. 2010 Jan;23(1):34-8. doi:
10.1097/01.ASW.0000363485.17224.26.
Randomized comparison of OASIS wound matrix versus moist wound dressing in the
treatment of difficult-to-heal wounds of mixed arterial/venous etiology.
Romanelli M(1), Dini V, Bertone MS.
Author information:
(1)Department of Dermatology, University of Pisa, Italy.
OBJECTIVE: In this study, a biological extracellular matrix was compared with a
moist wound dressing to determine its effectiveness in the treatment of mixed
arterial/venous and venous ulcers.
METHODS: Patients were evaluated for complete wound healing, time to dressing
change, and formation of granulation tissue.
RESULTS: Extracellular matrix-treated ulcers achieved complete healing on average
in 5.4 weeks as compared with 8.3 weeks for the control group treated with moist
wound dressing (P = .02). At the primary time point evaluated (8 weeks), complete
wound closure was achieved in 80% of extracellular matrix-treated ulcers compared
with 65% of ulcers in the control group (P < .05). Statistically significant
differences favoring the extracellular-matrix treatment group were also reported
for time to dressing change (P < .05), and for percentage of granulation tissue
formed (P < .05).
CONCLUSION: Overall, the biological extracellular matrix was more beneficial than
moist wound dressings for the treatment of patients with mixed arterial/venous or
venous ulcers.
DOI: 10.1097/01.ASW.0000363485.17224.26
PMID: 20101114 [Indexed for MEDLINE]
Appears in following Topics:
