Sauder DN, Kilian PL, McLane JA, Quick TW, Jakubovic H, Davis SC, Eaglstein WH, Mertz PM, et al.
Lymphokine research. Date of publication 1990 Jan 1;volume 9(4):465-73.
1. Lymphokine Res. 1990 Winter;9(4):465-73.
Interleukin-1 enhances epidermal wound healing.
Sauder DN(1), Kilian PL, McLane JA, Quick TW, Jakubovic H, Davis SC, Eaglstein
WH, Mertz PM.
Author information:
(1)Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
Previous in vitro studies suggest that the interleukin-1 (IL-1) proteins may be
important for skin function. Keratinocytes are known to synthesize IL-1 in
response to injury and IL-1 has been shown to stimulate fibroblast and
keratinocyte growth, collagen synthesis by fibroblasts, and chemotaxis of
keratinocytes. In order to evaluate the ability of IL-1 to enhance wound healing,
recombinant human IL-1 alpha was applied topically in a water-miscible cream to
partial thickness wounds made on the backs of pathogen-free adult pigs. The
wounded site was excised at various times for assessment of epidermal
regeneration. This study shows a statistically significant enhancement of healing
of the IL-1-treated wounds compared with either air-exposed or vehicle-treated
wounds. Histologic examination of biopsies from IL-1-treated wounds indicated
complete and architecturally normal epidermal regeneration. Porcine keratinocytes
and membranes prepared from porcine skin were found to possess high affinity
receptors for human IL-1 alpha. This study suggests that topical administration
of IL-1 may be useful for the promotion of wound healing.
PMID: 2151047 [Indexed for MEDLINE]
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