Barnett GC, West CM, Dunning AM, Elliott RM, Coles CE, Pharoah PD, Burnet NG, et al.
Nature reviews. Cancer. Date of publication 2009 Feb 1;volume 9(2):134-42.
1. Nat Rev Cancer. 2009 Feb;9(2):134-42. doi: 10.1038/nrc2587. Epub 2009 Jan 16.
Normal tissue reactions to radiotherapy: towards tailoring treatment dose by
genotype.
Barnett GC(1), West CM, Dunning AM, Elliott RM, Coles CE, Pharoah PD, Burnet NG.
Author information:
(1)Department of Oncology, University of Cambridge, Oncology Centre,
Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, UK.
gillbarnett@doctors.org.uk
A key challenge in radiotherapy is to maximize radiation doses to cancer cells
while minimizing damage to surrounding healthy tissue. As severe toxicity in a
minority of patients limits the doses that can be safely given to the majority,
there is interest in developing a test to measure an individual's
radiosensitivity before treatment. Variation in sensitivity to radiation is an
inherited genetic trait and recent progress in genotyping raises the possibility
of genome-wide studies to characterize genetic profiles that predict patient
response to radiotherapy.
DOI: 10.1038/nrc2587
PMCID: PMC2670578
PMID: 19148183 [Indexed for MEDLINE]
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