Denham JW, Hauer-Jensen M, et al.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncol.... Date of publication 2002 May 1;volume 63(2):129-45.
1. Radiother Oncol. 2002 May;63(2):129-45.
The radiotherapeutic injury--a complex 'wound'.
Denham JW(1), Hauer-Jensen M.
Author information:
(1)Department of Radiation Oncology, Newcastle Mater Misericordiae Hospital,
Newcastle University, Locked Bag 7, Hunter Region Mail Centre, NSW 2310,
Newcastle, Australia.
Radiotherapeutic normal tissue injury can be viewed as two simultaneously ongoing
and interacting processes. The first has many features in common with the healing
of traumatic wounds. The second is a set of transient or permanent alterations of
cellular and extracellular components within the irradiated volume. In contrast
to physical trauma, fractionated radiation therapy produces a series of repeated
insults to tissues that undergo significant changes during the course of
radiotherapy. Normal tissue responses are also influenced by rate of dose
accumulation and other factors that relate to the radiation therapy schedule.
This article reviews the principles of organised normal tissue responses during
and after radiation therapy, the effect of radiation therapy on these responses,
as well as some of the mechanisms underlying the development of recognisable
injury. Important clinical implications relevant to these processes are also
discussed.
PMID: 12063002 [Indexed for MEDLINE]
Appears in following Topics:
