Müller E, van Leen MW, Bergemann R, et al.
PharmacoEconomics. Date of publication 2001 Jan 1;volume 19(12):1209-16.
1. Pharmacoeconomics. 2001;19(12):1209-16.
Economic evaluation of collagenase-containing ointment and hydrocolloid dressing
in the treatment of pressure ulcers.
Müller E(1), van Leen MW, Bergemann R.
Author information:
(1)Institute for Medical Outcome Research, Loerrach, Germany.
elvira.mueller@imor.com
OBJECTIVE: To evaluate the efficacy and cost effectiveness of two treatments of
pressure sores on the heel: a collagenase-containing ointment and a hydrocolloid
dressing.
DESIGN: Study and cost data were collected prospectively in a randomised clinical
trial in The Netherlands by counting the resource use for each patient until
wound healing occurred.
STUDY PARTICIPANTS: All 24 female study participants were inpatients from the
same hospital with grade IV pressure sores on the heel following orthopaedic
surgery.
INTERVENTIONS: Two different treatment strategies were analysed: a
collagenase-containing ointment (Novuxol) and a hydrocolloid dressing (Duoderm).
PERSPECTIVE: Hospital perspective.
MAIN OUTCOME MEASURES AND RESULTS: The average costs per patient for treatment
with the hydrocolloid dressing were about 5% higher than those with the
collagenase-containing ointment. The treatment costs were similarly distributed
within both groups, with 34% for materials and 66% for personnel. The
cost-effectiveness analysis revealed that cost savings of 899 Dutch guilders
(1998 values) per successfully treated patient could be expected using the
collagenase-containing ointment instead of the hydrocolloid dressing. In
addition, wound healing was achieved, on average, within a shorter time period
with the collagenase treatment (10 weeks) compared with the hydrocolloid
treatment (14 weeks). The robustness of the results were also tested using
sensitivity analyses. These analyses served to confirm that collagenase treatment
provides a better cost-effectiveness ratio than hydrocolloid treatment.
CONCLUSIONS: With regard to overall costs and costs per successfully treated
patient, this study showed collagenase treatment to be more cost effective than
the hydrocolloid treatment in patients with grade IV pressure sores on the heel
and that the amount of time needed for wound healing was shorter.
PMID: 11772156 [Indexed for MEDLINE]
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