Jeffcoate WJ, Harding KG, et al.
Lancet (London, England). Date of publication 2003 May 3;volume 361(9368):1545-51.
1. Lancet. 2003 May 3;361(9368):1545-51.
Diabetic foot ulcers.
Jeffcoate WJ(1), Harding KG.
Author information:
(1)Department of Diabetes and Endocrinology, City Hospital, Nottingham, UK.
jeffcoate@bigfoot.com
Comment in
Lancet. 2003 Nov 29;362(9398):1858.
Ulceration of the foot in diabetes is common and disabling and frequently leads
to amputation of the leg. Mortality is high and healed ulcers often recur. The
pathogenesis of foot ulceration is complex, clinical presentation variable, and
management requires early expert assessment. Interventions should be directed at
infection, peripheral ischaemia, and abnormal pressure loading caused by
peripheral neuropathy and limited joint mobility. Despite treatment, ulcers
readily become chronic wounds. Diabetic foot ulcers have been neglected in
health-care research and planning, and clinical practice is based more on opinion
than scientific fact. Furthermore, the pathological processes are poorly
understood and poorly taught and communication between the many specialties
involved is disjointed and insensitive to the needs of patients.
DOI: 10.1016/S0140-6736(03)13169-8
PMID: 12737879 [Indexed for MEDLINE]
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