Cucchiari D, Torregrosa JV, et al.
Nefrologia. Date of publication 2018 Nov 1;volume 38(6):579-586.
1. Nefrologia (Engl Ed). 2018 Nov-Dec;38(6):579-586. doi:
10.1016/j.nefro.2018.05.007. Epub 2018 Nov 8.
Calciphylaxis in patients with chronic kidney disease: A disease which is still
bewildering and potentially fatal.
[Article in English, Spanish]
Cucchiari D(1), Torregrosa JV(2).
Author information:
(1)Servicio de Nefrología y Trasplante Renal, Hospital Clínic, Barcelona,
España; Nephrology and Dialysis Unit, Humanitas Clinical Research Center,
Rozzano, Italia.
(2)Servicio de Nefrología y Trasplante Renal, Hospital Clínic, Barcelona,
España. Electronic address: vtorre@clinic.cat.
Calciphylaxis, also known as calcific uraemic arteriolopathy, is a rare syndrome
that typically causes skin necrosis and usually affects dialysis patients. Its
pathogenesis is multifactorial and is the consequence of many factors causing
ectopic calcifications in patients with chronic kidney disease, such as
calcium-phosphate metabolism disorders, hyper- or hypo-parathyroidism, diabetes,
obesity, systemic inflammation and the use of vitamin K antagonists, among
others. From a clinical point of view, calciphylaxis may progress from painful
purpura to extensive areas of skin necrosis that can potentially lead to
superinfection and the death of the patient due to sepsis. Treatment is
primarily based on managing the wounds, eliminating all the possible
precipitating factors of ectopic calcification and administering agents which
are capable of inhibiting the process of calcification.
Copyright © 2018 Sociedad Española de Nefrología. Published by Elsevier España,
S.L.U. All rights reserved.
DOI: 10.1016/j.nefro.2018.05.007
PMID: 30415999 [Indexed for MEDLINE]
