Ajayi OD, Gaskill Z, Kelly M, Logue CJ, Hendricksen SM, et al.
Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc. Date of publication 2020 Oct 1;volume 47(4):581-589.
1. Undersea Hyperb Med. 2020 Fourth Quarter;47(4):581-589. doi:
10.22462/10.12.2020.7.
A comparison of two hyperbaric oxygen regimens: 2.0 ATA for 120 minutes to 2.4
ATA for 90 minutes in treating radiation-induced cystitis Are these regimens
equivalent?
Ajayi OD(1), Gaskill Z(2), Kelly M(2), Logue CJ(1)(3), Hendricksen SM(1)(3).
Author information:
(1)Division of Hyperbaric Medicine, Department of Emergency Medicine, Hennepin
Healthcare, Minneapolis, Minnesota U.S.
(2)Division of Hyperbaric Medicine, Department of Emergency Medicine, University
of Pennsylvania, Philadelphia, Pennsylvania U.S.
(3)University of Minnesota Medical School, Minneapolis, Minnesota U.S.
INTRODUCTION: Hyperbaric oxygen dosing variations exist in radiation cystitis
treatment. The objectives of this study were to compare response and safety
rates among patients with radiation cystitis treated with different protocols:
2.0 ATA (atmospheres absolute) for 120 minutes at the University of
Pennsylvania; and 2.4 ATA for 90 minutes at Hennepin Healthcare.
MATERIALS AND METHODS: Retrospective chart review of radiation cystitis patients
treated with hyperbaric oxygen at the University of Pennsylvania (January
2010-December 2018) and Hennepin Healthcare Minnesota (January 2014-December
2018). Primary outcome was response to treatment. Complications were limited to
hyperbaric-related conditions. Regression analysis was performed with ordinal
logistic regression and binary logistic regression.
RESULT: 126 patients were included in the analysis (2.0 ATA: 66, 2.4 ATA: 60).
Overall response rate was 75.4% (good) and was not significantly different
between protocols (good response: 2.0 ATA 72.7% vs. 2.4 ATA 78.3% p=0.74). The
2.0 ATA group required additional treatments [2.0 ATA: 45.45 ± 14.5 vs. 2.4 ATA:
40.03 ± 9.7, p<0.05]. 6.1% (2.0 ATA) and 13.3% (2.4 ATA) required tympanostomy
tube placement or needle myringotomy for otic barotrauma (p=0.22). Transfusion
was associated with poorer outcomes (p<0.05).
CONCLUSION: Both groups - 2.0 ATA and 2.4 ATA - had similar response and
complication rates. Blood transfusion is a negative prognostic factor for
treatment outcome.
Copyright© Undersea and Hyperbaric Medical Society.
DOI: 10.22462/10.12.2020.7
PMID: 33227834 [Indexed for MEDLINE]
Conflict of interest statement: The authors of this paper declare no conflicts
of interest exist with this submission.
