Author(s) Marx RE, Ehler WJ, Tayapongsak P, Pierce LW, et al.

Journal American journal of surgery. Date of publication 1990 Nov 1;volume 160(5):519-24.

Abstract 1. Am J Surg. 1990 Nov;160(5):519-24. doi: 10.1016/s0002-9610(05)81019-0. Relationship of oxygen dose to angiogenesis induction in irradiated tissue. Marx RE(1), Ehler WJ, Tayapongsak P, Pierce LW. Author information: (1)Division of Oral and Maxillofacial Surgery, University of Miami School of Medicine/Jackson Memorial Medical Center, Florida. Comment in Am J Surg. 1992 Apr;163(4):457. doi: 10.1016/0002-9610(92)90054-u. Am J Surg. 1994 May;167(5):551. doi: 10.1016/0002-9610(94)90258-5. This study was accomplished in an irradiated rabbit model to assess the angiogenic properties of normobaric oxygen and hyperbaric oxygen as compared with air-breathing controls. Results indicated that normobaric oxygen had no angiogenic properties above normal revascularization of irradiated tissue than did air-breathing controls (p = 0.89). Hyperbaric oxygen demonstrated an eight- to ninefold increased vascular density over both normobaric oxygen and air-breathing controls (p = 0.001). Irradiated tissue develops a hypovascular-hypocellular-hypoxic tissue that does not revascularize spontaneously. Results failed to demonstrate an angiogenic effect of normobaric oxygen. It is suggested that oxygen in this sense is a drug requiring hyperbaric pressures to generate therapeutic effects on chronically hypovascular irradiated tissue. DOI: 10.1016/s0002-9610(05)81019-0 PMID: 2240387 [Indexed for MEDLINE]

Source ID (e.g. PMID): 2240387