Lullove EJ, Liden B, Winters C, McEneaney P, Raphael A, Lantis Ii JC, et al.
Wounds : a compendium of clinical research and practice. Date of publication 2021 Jul 1;volume 33(7):169-177.
1. Wounds. 2021 Jul;33(7):169-177. doi: 10.25270/wnds/2021.169177. Epub 2021 Apr
14.
A Multicenter, Blinded, Randomized Controlled Clinical Trial Evaluating the
Effect of Omega-3-Rich Fish Skin in the Treatment of Chronic, Nonresponsive
Diabetic Foot Ulcers.
Lullove EJ(1), Liden B(2), Winters C(3), McEneaney P(4), Raphael A(5), Lantis Ii
JC(6).
Author information:
(1)West Boca Center for Wound Healing, Coconut Creek, Florida.
(2)Surgical Services, Berger Health System, Circleville, Ohio.
(3)Department of Surgery, St Vincent Hospital, Indianapolis, Indiana.
(4)Northern Illinois Foot and Ankle Specialists, Crystal Lake, Illinois.
(5)Village Podiatry Centers, Smyrna, Georgia.
(6)Department of Surgery, Icahn School of Medicine, Mount Sinai Morningside and
West Hospitals, New York, New York.
INTRODUCTION: Omega-3-rich fish skin grafts have been shown to accelerate wound
healing in full-thickness wounds.
OBJECTIVE: The goal of this study was to compare the fish skin graft with
standard of care (SOC) using collagen alginate dressing in the management of
treatment-resistant diabetic foot ulcers (DFUs), defined as superficial ulcers
not involving tendon capsule or bone.
MATERIALS AND METHODS: Patients with DFUs who were first treated with SOC
(offloading, appropriate debridement, and moist wound care) for a 2-week
screening period were then randomized to either receiving SOC alone or SOC plus
fish skin graft applied weekly for up to 12 weeks. The primary endpoint was the
percentage of wounds closed at 12 weeks.
RESULTS: Forty-nine patients were included in the final analysis. At 12 weeks,
16 of 24 patients' DFUs (67%) in the fish skin arm were completely closed,
compared with 8 of 25 patients' DFUs (32%) in the SOC arm (P value = .0152 [N =
49]; significant at P < .047). At 6 weeks, the percentage area reduction was
41.2% in the SOC arm and 72.8% in the fish skin arm.
CONCLUSIONS: The application of fish skin graft to previously nonresponsive DFUs
resulted in significantly more fully healed wounds at 12 weeks than SOC alone.
The study findings support the use of fish skin graft for chronic DFUs that do
not heal with comprehensive SOC treatment.
DOI: 10.25270/wnds/2021.169177
PMID: 33872197 [Indexed for MEDLINE]
