Luthringer M, Mukherjee T, Arguello-Angarita M, Granick MS, Alvarez OM, et al.
Wounds : a compendium of clinical research and practice. Date of publication 2020 Feb 1;volume 32(2):57-65.
1. Wounds. 2020 Feb;32(2):57-65.
Human-derived Acellular Dermal Matrix Grafts for Treatment of Diabetic Foot
Ulcers: A Systematic Review and Meta-analysis.
Luthringer M(1), Mukherjee T(1), Arguello-Angarita M(1), Granick MS(1), Alvarez
OM(1).
Author information:
(1)Rutgers New Jersey Medical School, Division of Plastic Surgery, Newark, NJ.
BACKGROUND: Treating diabetic foot ulcers (DFUs) requires thorough understanding
of available surgical tools.
OBJECTIVE: This meta-analysis compares human-derived acellular dermal matrices
(H-ADMs) with standard of care (SOC) to evaluate the number of healed ulcers at
12 and 16 weeks and number of days to complete healing. As a secondary outcome,
the efficacy of 3 H-ADM subtypes are studied.
METHODS: Two researchers searched PubMed, EMBASE, and The Cochrane Central
Register of Controlled Trials for relevant titles from inception through July
2018. Inclusion criteria indicated articles be randomized controlled trials
investigating the effects on neuropathic, nonischemic DFUs.
RESULTS: Data from 312 DFUs in total were included in the meta-analysis. The
results show H-ADMs are more effective in healing patients within a 12-week
(3.14; range, 2.04-4.83) and 16-week period (2.35; range, 1.25-4.43) in
comparison with SOC. Further, the mean time to complete healing was shorter in
the H-ADM group (-2.31 days; range, -2.67 to -1.95 days) in comparison with SOC.
Within the subgroups, 2 H-ADMs were associated with a higher likelihood of
complete healing within 12 weeks when compared with SOC. The third H-ADM had a
point estimate, which suggested superiority over SOC.
CONCLUSIONS: This study shows H-ADMs are associated with a higher likelihood of
complete healing and fewer days to complete healing within a 12-week and 16-week
periods when compared with SOC. Also, the commercial products performed
similarly.
PMID: 32155123 [Indexed for MEDLINE]
