Alomairi AA, Alhatlani RA, Alharbi SM, Alqurain ZJ, Alanazi IZ, Alanazi SA, Alkhmis Z, Samandar AF, Arif S, et al.
Cureus. Date of publication 2024 Mar 21;volume 16(3):e56659.
1. Cureus. 2024 Mar 21;16(3):e56659. doi: 10.7759/cureus.56659. eCollection 2024
Mar.
Assessing the Application and Effectiveness of Human Amniotic Membrane in the
Management of Venous and Diabetic Ulcers: A Systematic Review and Meta-Analysis
of Randomized Controlled Trials.
Alomairi AA(1), Alhatlani RA(2), Alharbi SM(3), Alqurain ZJ(4), Alanazi IZ(5),
Alanazi SA(5), Alkhmis Z(6), Samandar AF(7), Arif S(8).
Author information:
(1)College of Medicine, King Saud Bin Abdulaziz University for Health Sciences,
Riyadh, SAU.
(2)College of Medicine, Unaizah College of Medicine and Medical Sciences, Qassim
University, Qassim, SAU.
(3)College of Medicine, King Abdulaziz University, Jeddah, SAU.
(4)College of Medicine, Batterjee Medical College, Jeddah, SAU.
(5)Medicine, Northern Border University, Arar, SAU.
(6)Medicine and Surgery, King Faisal University, Alhasa, SAU.
(7)College of Medicine, Umm AlQura University - Al-Qunfudah Branch, Mecca, SAU.
(8)Department of Plastic Surgery and Burn Unit, Security Force Hospital, Riyadh,
SAU.
This study aimed to assess the efficacy of human amniotic membranes (HAM) in
treating venous and diabetic ulcers, which often pose challenges in healing. A
systematic review and meta-analysis were conducted, evaluating 10 relevant
studies involving 633 participants. Findings revealed that HAM treatment
significantly accelerated ulcer closure, demonstrating over 90% complete healing
compared to standard care. Despite moderate heterogeneity among studies, the
results strongly suggested the effectiveness and safety of HAM therapy for
venous and diabetic leg ulcers. Further research with larger study cohorts is
recommended to bolster the existing evidence supporting HAM in managing these
challenging wounds.
Copyright © 2024, Alomairi et al.
DOI: 10.7759/cureus.56659
PMCID: PMC11032220
PMID: 38646232
Conflict of interest statement: The authors have declared that no competing
interests exist.
