Dang B, Gamage S, Sethi S, Jensen ED, Sambrook P, Goss A, et al.
Australian dental journal. Date of publication 2023 Sep 1;volume 68(3):171-178.
1. Aust Dent J. 2023 Sep;68(3):171-178. doi: 10.1111/adj.12963. Epub 2023 Jun 22.
The role of hyperbaric oxygen in osteoradionecrosis-a prophylactic insight.
Dang B(1)(2), Gamage S(1)(2), Sethi S(2), Jensen ED(1)(2), Sambrook P(1)(2),
Goss A(1)(2).
Author information:
(1)Oral and Maxillofacial Surgery Unit, Royal Adelaide Hospital, Adelaide, South
Australia, Australia.
(2)Adelaide Dental School, The University of Adelaide, Adelaide, South
Australia, Australia.
BACKGROUND: Osteoradionecrosis (ORN) is an uncommon and debilitating consequence
of head and neck radiotherapy and hyperbaric oxygen therapy (HBOT) has been
advocated for prophylaxis prior to performing dentoalveolar procedures. The aim
of this study was to evaluate a prophylactic HBOT protocol and describe the
outcomes of susceptible individuals.
METHODS: A retrospective audit of adults who attended the Oral and Maxillofacial
Surgery department at the Royal Adelaide Hospital (South Australia) who received
dental extractions with a history of radiotherapy to the jaws from 2008 to 2020.
Data including demographic information and outcomes of osteoradionecrosis and
delayed healing was recorded.
RESULTS: A total of 121 individuals were eligible for case note review; 68.6% of
individuals were male and 55.4% were aged over 67 years. Osteoradionecrosis
occurred in 9.1% of individuals and delayed healing for 3.3%; fifteen
individuals (12.4%) were unable to complete the HBOT protocol. The individuals
who were diagnosed with ORN had a significant association with age (P = 0.006)
and binary analysis showed alcohol consumption to be a significant predictor.
CONCLUSIONS: Prophylactic HBOT protocol had a lower proportion of individuals
diagnosed with ORN and those who were diagnosed were more likely to be younger
males and have current alcohol consumption.
© 2023 The Authors. Australian Dental Journal published by John Wiley & Sons
Australia, Ltd on behalf of Australian Dental Association.
DOI: 10.1111/adj.12963
PMID: 37345410 [Indexed for MEDLINE]
