Chen HR, Lu SJ, Wang Q, Li ML, Chen XC, Pan BY, et al.
International wound journal. Date of publication 2024 Apr 1;volume 21(4):e14621.
1. Int Wound J. 2024 Apr;21(4):e14621. doi: 10.1111/iwj.14621.
Application of hyperbaric oxygen therapy in diabetic foot ulcers: A
meta-analysis.
Chen HR(1), Lu SJ(2), Wang Q(1), Li ML(1), Chen XC(1), Pan BY(1).
Author information:
(1)Department of General Practice Medicine, Affiliated Haikou Hospital of
Xiangya Medical College of Central South University, Haikou, China.
(2)Department of Cardiovascular Medicine, Affiliated Haikou Hospital of Xiangya
Medical College of Central South University, Haikou, China.
Hyperbaric oxygen therapy (HBOT) has been used in patients with diabetic foot
ulcers (DFU) for many years, but its clinical efficacy is still controversial.
Therefore, this study explored the efficacy of HBOT applied to DFU by means of
meta-analysis. PubMed, Cochrane Library, Embase, CNKI and Wanfang databases were
searched, from database inception to October 2023, and published randomised
controlled trials (RCTs) of HBOT in DFU were collected. Two investigators
independently screened the collected literature, extracted relevant data and
assessed the quality of the literature. Review Manager 5.4 software was applied
for data analysis. Twenty-nine RCTs with 1764 patients were included. According
to the combined results, when compared with conventional treatment, HBOT
significantly increased the complete healing rate of DFUs (46.76% vs. 24.46%,
odds ratio [OR]: 2.83, 95% CI: 2.29-3.51, p < 0.00001) and decreased the
amputation rate (26.03% vs. 45.00%, OR: 0.41, 95% CI: 0.18-0.95, p = 0.04), but
the incidence of adverse events was significantly higher in patients (17.37% vs.
8.27%, OR: 2.49, 95% CI: 1.35-4.57, p = 0.003), whereas there was no significant
difference in the mortality (6.96% vs. 12.71%, OR: 0.52, 95% CI: 0.21-1.28,
p = 0.16). Our results suggest that HBOT is effective in increasing the complete
healing rate and decreasing the amputation rate in patients with DFUs, but
increases the incidence of adverse events, while it has no significant effect on
mortality.
© 2024 The Authors. International Wound Journal published by
Medicalhelplines.com Inc and John Wiley & Sons Ltd.
DOI: 10.1111/iwj.14621
PMCID: PMC10965274
PMID: 38531355 [Indexed for MEDLINE]
Conflict of interest statement: The authors declare that there is no conflict of
interest.
