Kim H, Kong SK, Kim J, Lee HM, Choi SW, Lee IW, Oh SJ, et al.
The Laryngoscope. Date of publication 2023 Feb 1;volume 133(2):383-388.
1. Laryngoscope. 2023 Feb;133(2):383-388. doi: 10.1002/lary.30181. Epub 2022 May
12.
The Optimized Protocol of Hyperbaric Oxygen Therapy For Sudden Sensorineural
Hearing Loss.
Kim H(1), Kong SK(1)(2), Kim J(1), Lee HM(3), Choi SW(1), Lee IW(2)(3), Oh
SJ(1)(2).
Author information:
(1)Department of Otorhinolaryngology and Biomedical Research Institute, Pusan
National University Hospital, Busan, Republic of Korea.
(2)Department of Otorhinolaryngology, College of Medicine, Pusan National
University, Busan, Republic of Korea.
(3)Department of Otorhinolaryngology and Biomedical Research Institute, Yangsan
Pusan National University Hospital, Yangsan, Republic of Korea.
OBJECTIVE: This study aimed to determine the optimal protocol of hyperbaric
oxygen therapy (HBOT) according to various treatment settings for sudden
sensorineural hearing loss (SSNHL).
METHODS: A 112 patients with SSNHL were enrolled in this prospective study. All
patients were treated with systemic steroid therapy, intratympanic steroid
therapy, and HBOT. According to the pressure and duration of HBOT (10 sessions
in total), the patients were divided into three groups: group 1, 2.5 atmospheres
absolute (ATA) for 1 h; group 2, 2.5 ATA for 2 h; and group 3, 1.5 ATA for 1 h.
The pure-tone average (PTA), word discrimination score (WDS), and mean gain were
compared.
RESULTS: A total of 105 patients completed the 3-month follow-up, and 6 patients
were excluded. Differences among groups were found in PTA, WDS, and mean gain.
In the post-hoc analysis, group 3 had significantly lower WDS and mean gain than
groups 1 and 2; however, group 2 showed no significant differences from group 1.
The proportion of patients with hearing recovery after treatment was
significantly higher in group 1 (57.6%) and group 2 (58.8%) than in group 3
(31.3%).
CONCLUSIONS: When HBOT (10 sessions) was combined with corticosteroids as the
initial therapy for SSNHL, a higher pressure (1.5 ATA vs. 2.5 ATA) provided
better treatment results; however, increasing the duration (1 h vs. 2 h) under
2.5 ATA did not result in a significant difference. Therefore, HBOT for SSNHL
may be performed at 2.5 ATA for 1 h in 10 sessions. Laryngoscope, 133:383-388,
2023.
© 2022 The American Laryngological, Rhinological and Otological Society, Inc.
DOI: 10.1002/lary.30181
PMID: 35548932 [Indexed for MEDLINE]
