De Wolde SD, Hulskes RH, Weenink RP, Hollmann MW, Van Hulst RA, et al.
Biomolecules. Date of publication 2021 Aug 14;volume 11(8):.
1. Biomolecules. 2021 Aug 14;11(8):1210. doi: 10.3390/biom11081210.
The Effects of Hyperbaric Oxygenation on Oxidative Stress, Inflammation and
Angiogenesis.
De Wolde SD(1)(2), Hulskes RH(1)(3), Weenink RP(1)(2), Hollmann MW(1), Van Hulst
RA(1)(2).
Author information:
(1)Department of Anesthesiology, Amsterdam University Medical Centers, Location
AMC, 1105 AZ Amsterdam, The Netherlands.
(2)Department of Hyperbaric Medicine, Amsterdam University Medical Centers,
Location AMC, 1105 AZ Amsterdam, The Netherlands.
(3)Department of Surgery, Amsterdam University Medical Centers, Location AMC,
1105 AZ Amsterdam, The Netherlands.
Hyperbaric oxygen therapy (HBOT) is commonly used as treatment in several
diseases, such as non-healing chronic wounds, late radiation injuries and carbon
monoxide poisoning. Ongoing research into HBOT has shown that preconditioning
for surgery is a potential new treatment application, which may reduce
complication rates and hospital stay. In this review, the effect of HBOT on
oxidative stress, inflammation and angiogenesis is investigated to better
understand the potential mechanisms underlying preconditioning for surgery using
HBOT. A systematic search was conducted to retrieve studies measuring markers of
oxidative stress, inflammation, or angiogenesis in humans. Analysis of the
included studies showed that HBOT-induced oxidative stress reduces the
concentrations of pro-inflammatory acute phase proteins, interleukins and
cytokines and increases growth factors and other pro-angiogenesis cytokines.
Several articles only noted this surge after the first HBOT session or for a
short duration after each session. The anti-inflammatory status following HBOT
may be mediated by hyperoxia interfering with NF-κB and IκBα. Further research
into the effect of HBOT on inflammation and angiogenesis is needed to determine
the implications of these findings for clinical practice.
DOI: 10.3390/biom11081210
PMCID: PMC8394403
PMID: 34439876 [Indexed for MEDLINE]
Conflict of interest statement: The authors declare no conflict of interest.
