Memar MY, Yekani M, Alizadeh N, Baghi HB, et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. Date of publication 2019 Jan 1;volume 109():440-447.
1. Biomed Pharmacother. 2019 Jan;109:440-447. doi: 10.1016/j.biopha.2018.10.142.
Epub 2018 Nov 3.
Hyperbaric oxygen therapy: Antimicrobial mechanisms and clinical application for
infections.
Memar MY(1), Yekani M(2), Alizadeh N(3), Baghi HB(4).
Author information:
(1)Immunology Research Center, Tabriz University of Medical Sciences, Tabriz,
Iran; Infectious and Tropical Diseases Research Center, Tabriz University of
Medical Sciences, Tabriz, Iran.
(2)Immunology Research Center, Tabriz University of Medical Sciences, Tabriz,
Iran; Drug Applied Research Center, Tabriz University of Medical Sciences,
Tabriz, Iran.
(3)Students' Research Committee, Tabriz University of Medical Sciences, Tabriz,
Iran; Department of Microbiology, Faculty of Medicine, Tabriz University of
Medical Sciences, Tabriz, Iran.
(4)Immunology Research Center, Tabriz University of Medical Sciences, Tabriz,
Iran; Infectious and Tropical Diseases Research Center, Tabriz University of
Medical Sciences, Tabriz, Iran; Department of Microbiology, Faculty of Medicine,
Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address:
hbannazadeh@tbzmed.ac.ir.
Hyperbaric oxygen therapy (HBOT) is a treatment procedure that involves
breathing 100% O2 for a certain time and under a certain pressure. HBOT is
commonly administrated as a primary or alternative therapy for different
diseases such as infections. In this paper, we reviewed the general aspect of
HBOT procedures, the mechanisms of antimicrobial effects and the application in
the treatment of infections. Parts of the antimicrobial effects of HBOT are
believed to result of reactive from the formation of reactive oxygen species
(ROS). It is also said that HBOT enhances the antimicrobial effects of the
immune system and has an additive or synergistic effect with certain
antimicrobial agents. HBOT has been described as a useful procedure for
different infections, particularly in deep and chronic infections such as
necrotizing fasciitis, osteomyelitis, chronic soft tissue infections, and
infective endocarditis. The anti-inflammation property of HBOT has demonstrated
that it may play a significant role in decreasing tissue damage and infection
expansion. Patients treated by HBOT need carful pre-examination and monitoring.
If safety standards are strictly tracked, HBOT can be considered a suitable
procedure with an apt rate of complication.
Copyright © 2018 Elsevier Masson SAS. All rights reserved.
DOI: 10.1016/j.biopha.2018.10.142
PMID: 30399579 [Indexed for MEDLINE]
