Liao SC, Shao SC, Yang KJ, Yang CC, et al.
Scientific reports. Date of publication 2021 Sep 28;volume 11(1):19212.
1. Sci Rep. 2021 Sep 28;11(1):19212. doi: 10.1038/s41598-021-98539-y.
Real-world effectiveness of hyperbaric oxygen therapy for delayed
neuropsychiatric sequelae after carbon monoxide poisoning.
Liao SC(1)(2), Shao SC(3)(4), Yang KJ(5)(6), Yang CC(7)(8).
Author information:
(1)Department of Emergency Medicine, Chang Gung Memorial Hospital, Keelung,
Taiwan.
(2)College of Medicine, Chang Gung University, Taoyuan, Taiwan.
(3)School of Pharmacy, Institute of Clinical Pharmacy and Pharmaceutical
Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
(4)Department of Pharmacy, Keelung Chang Gung Memorial Hospital, Keelung,
Taiwan.
(5)Division of Hyperbaric Oxygen Center, Chang Gung Memorial Hospital and Chang
Gung University College of Medicine, Taoyuan, Taiwan.
(6)Department of Emergency Medicine, Chang Gung Memorial Hospital, Linkou,
Taiwan.
(7)Institute of Environmental and Occupational Health Sciences, School of
Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
ccyang@vghtpe.gov.tw.
(8)Division of Clinical Toxicology & Occupational Medicine, Department of
Medicine, Taipei Veterans General Hospital, 201 Shih-Pai Road Section 2, Taipei,
11217, Taiwan. ccyang@vghtpe.gov.tw.
To assess real-world effectiveness of hyperbaric oxygen therapy (HBOT) on
delayed neuropsychiatric sequelae (DNS) after carbon monoxide (CO) poisoning we
conducted a retrospective review of patients with CO poisoning admitted to
Linkou Chang-Gung Memorial Hospital, Taiwan's largest medical center, during
2009-2015. We included patients developing DNS after CO poisoning and compared
improvements in neuropsychiatric function, with and without HBOT, after
12 months post-DNS to understand differences in recovery rates. DNS
improvement-associated factors were also evaluated. We used receiver operating
characteristic (ROC) curve analysis to assess the role of time elapsed between
DNS diagnosis and HBOT initiation in predicting DNS improvement. A total of 62
patients developed DNS, of whom 11 recovered while the rest did not. Possible
factors predicting DNS improvement included receiving HBOT post-DNS (72.7% vs
25.5%; P = 0.006), and treatment with more than three HBOT sessions during acute
stage CO poisoning (81.8% vs 27.5%; P = 0.003). The relevant area under the ROC
curve was 0.789 (95% CI 0.603-0.974), and the best cut-off point was 3 days
post-DNS diagnosis, with 87.5% sensitivity and 61.5% specificity. Early HBOT in
patients who developed DNS after CO poisoning significantly improved their DNS
symptoms, with treatment effects sustained for 1 year after DNS diagnosis.
© 2021. The Author(s).
DOI: 10.1038/s41598-021-98539-y
PMCID: PMC8479087
PMID: 34584153 [Indexed for MEDLINE]
Conflict of interest statement: The authors declare no competing interests.
