Huang F, Huang Y, Huang X, Wang S, Peng Z, et al.
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. Date of publication 2023 Nov 28;volume 48(11):1669-1677.
1. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2023 Nov 28;48(11):1669-1677. doi:
10.11817/j.issn.1672-7347.2023.230240.
Effect of hyperbaric oxygen on symptoms of dementia in patients with delayed
encephalopathy after acute carbon monoxide poisoning.
Huang F(1), Huang Y(2), Huang X(2), Wang S(3), Peng Z(4).
Author information:
(1)Department of Hyperbaric Oxygen, Xiangya Hospital, Central South University,
Changsha 410008. hfl915@csu.edu.cn.
(2)Department of Hyperbaric Oxygen, Xiangya Hospital, Central South University,
Changsha 410008.
(3)Preventive Health Center, Xiangya Hospital, Central South University,
Changsha 410008, China.
(4)Department of Hyperbaric Oxygen, Xiangya Hospital, Central South University,
Changsha 410008. 13873151139@163.com.
OBJECTIVES: Delayed encephalopathy after acute carbon monoxide poisoning
(DEACMP) is the most severe complication of carbon monoxide poisoning, which
seriously endangers patients' quality of life. This study aims to investigate
the efficacy of hyperbaric oxygen (HBO2) on improving dementia symptoms in
patients with DEACMP.
METHODS: A retrospective analysis was performed on DEACMP patients, who visited
Xiangya Hospital, Central South University from June 2014 to June 2020. Among
them, patients who received conventional drug treatment combined with HBO2
treatment were included in an HBO2 group, while those who only received
conventional drug treatment were included in a control group. HBO2 was
administered once daily. Patients in the HBO2 group received 6 courses of
treatment, with each course consisting of 10 sessions. The Hasegawa Dementia
Scale (HDS) was used to diagnose dementia, and the Clinical Dementia Rating
(CDR) was used to grade the severity of dementia for DEACMP. The Alzheimer's
Disease Assessment Scale-Cognitive Section (ADAS-Cog), the Functional Activities
Questionnaire (FAQ), the Neuropsychiatric Inventory (NPI), and the Clinician's
Interview-Based Impression of Change-Plus Caregiver Input (CIBIC-Plus) were
performed to assess cognitive function, ability to perform activities of daily
living (ADL), behavioral and psychological symptoms, and overall function. The
study further analyzed the results of objective examinations related to
patients' dementia symptoms, including magnetic resonance imaging detection of
white matter lesions and abnormal electroencephalogram (EEG). The changes of the
above indicators before and after treatment, as well as the differences between
the 2 groups after treatment were compared.
RESULTS: There was no significant difference in the HDS score and CDR grading
between the 2 groups before treatment (both P>0.05). After treatment, the score
of ADAS-Cog, FAQ, NPI, and CIBIC Plus grading of the 2 groups were significantly
improved, and the improvement of the above indicators in the HBO2 group was
greater than that in the control group (all P<0.05). The effective rate of the
HBO2 group in treating DEACMP was significantly higher than that of the control
group (89.47% vs 65.87%, P<0.05). The objective examination results (white
matter lesions and abnormal EEG) showed that the recovery of patients in the
HBO2 group was better than that in the control group.
CONCLUSIONS: Hyperbaric oxygen can significantly relieve the symptoms of
dementia in patients with DEACMP.
Publisher: 目的: 急性一氧化碳中毒迟发性脑病(delayed encephalopathy after acute carbon monoxide
poisoning，DEACMP)是一氧化碳中毒最严重的并发症，严重危害患者的生活质量。本研究旨在探讨高压氧(hyperbaric
oxygen，HBO2)改善DEACMP患者痴呆症状的疗效。方法:
对2014年6月至2020年6月就诊于中南大学湘雅医院的DEACMP患者进行回顾性分析。接受常规药物治疗联合HBO2治疗的患者纳入HBO2组，只接受常规药物治疗的纳入对照组。HBO2组每天接受1次HBO2治疗，10次为1个疗程，共完成6个疗程。使用长谷川痴呆量表(Hasegawa
Dementia Scale，HDS)诊断痴呆，并使用临床痴呆评定量表(Clinical Dementia
Rating，CDR)对痴呆严重程度进行分级。治疗前后分别使用阿尔茨海默病评定量表-认知部分(Alzheimer’s Disease Assessment
Scale-Cognitive Section，ADAS-Cog)、功能活动问卷(Functional Activities
Questionnaire，FAQ)、神经精神问卷(Neuropsychiatric
Inventory，NPI)及病情变化与医护的临床面询印象量表(Clinician’s Interview-Based Impression of
Change-Plus Caregiver Input，CIBIC-Plus)评估患者的认知功能、日常行为能力(activities of daily
living，ADL)、精神行为症状及整体状态变化。进一步分析与患者痴呆症状相关的客观检查结果，包括磁共振成像检测脑白质病变和异常脑电图(electroencephalogram，EEG)情况。比较治疗前后上述指标的改变及治疗后2组间的差异。结果:
治疗前HDS评分及CDR分级2组间差异均无统计学意义(均P>0.05)。治疗后2组的ADAS-Cog、FAQ、NPI评分及CIBIC-Plus分级均显著改善，且HBO2组上述指标的改善大于对照组(均P<0.05)。HBO2组治疗DEACMP有效率显著高于对照组(89.47%
vs 65.87%，P<0.05)。客观检查结果(脑白质病变和异常EEG)显示HBO2组患者的恢复情况均优于对照组。结论:
HBO2可有效改善DEACMP患者的痴呆症状。.
目的: 急性一氧化碳中毒迟发性脑病(delayed encephalopathy after acute carbon monoxide
poisoning，DEACMP)是一氧化碳中毒最严重的并发症，严重危害患者的生活质量。本研究旨在探讨高压氧(hyperbaric
oxygen，HBO2)改善DEACMP患者痴呆症状的疗效。
方法:
对2014年6月至2020年6月就诊于中南大学湘雅医院的DEACMP患者进行回顾性分析。接受常规药物治疗联合HBO2治疗的患者纳入HBO2组，只接受常规药物治疗的纳入对照组。HBO2组每天接受1次HBO2治疗，10次为1个疗程，共完成6个疗程。使用长谷川痴呆量表(Hasegawa
Dementia Scale，HDS)诊断痴呆，并使用临床痴呆评定量表(Clinical Dementia
Rating，CDR)对痴呆严重程度进行分级。治疗前后分别使用阿尔茨海默病评定量表-认知部分(Alzheimer’s Disease Assessment
Scale-Cognitive Section，ADAS-Cog)、功能活动问卷(Functional Activities
Questionnaire，FAQ)、神经精神问卷(Neuropsychiatric
Inventory，NPI)及病情变化与医护的临床面询印象量表(Clinician’s Interview-Based Impression of
Change-Plus Caregiver Input，CIBIC-Plus)评估患者的认知功能、日常行为能力(activities of daily
living，ADL)、精神行为症状及整体状态变化。进一步分析与患者痴呆症状相关的客观检查结果，包括磁共振成像检测脑白质病变和异常脑电图(electroencephalogram，EEG)情况。比较治疗前后上述指标的改变及治疗后2组间的差异。
结果:
治疗前HDS评分及CDR分级2组间差异均无统计学意义(均P>0.05)。治疗后2组的ADAS-Cog、FAQ、NPI评分及CIBIC-Plus分级均显著改善，且HBO2组上述指标的改善大于对照组(均P<0.05)。HBO2组治疗DEACMP有效率显著高于对照组(89.47%
vs 65.87%，P<0.05)。客观检查结果(脑白质病变和异常EEG)显示HBO2组患者的恢复情况均优于对照组。
结论: HBO2可有效改善DEACMP患者的痴呆症状。
DOI: 10.11817/j.issn.1672-7347.2023.230240
PMCID: PMC10929946
PMID: 38432857 [Indexed for MEDLINE]
Conflict of interest statement: The authors declare that they have no conflicts
of interest to disclose.
