Zhang L, Sun Q, Xin Q, Qin J, Zhang L, Wu D, Gao G, Xia Y, et al.
The American journal of emergency medicine. Date of publication 2021 Apr 1;volume 42():95-100.
1. Am J Emerg Med. 2021 Apr;42:95-100. doi: 10.1016/j.ajem.2021.01.021. Epub 2021
Jan 14.
Hyperbaric oxygen therapy mobilized circulating stem cells and improved delayed
encephalopathy after acute carbon monoxide poisoning with up-regulation of
brain-derived neurotrophic factor.
Zhang L(1), Sun Q(2), Xin Q(3), Qin J(4), Zhang L(5), Wu D(5), Gao G(6), Xia
Y(7).
Author information:
(1)Department of Special Medicine, School of Basic Medicine, Qingdao University,
Qingdao 266071, Shandong, China.
(2)Department of Special Medicine, School of Basic Medicine, Qingdao University,
Qingdao 266071, Shandong, China; Department of Military and Special Medicine,
No.971 Hospital of The People's Liberation Army Navy, Qingdao 266071, Shandong,
China.
(3)Department of General Surgery, No.971 Hospital of The People's Liberation
Army Navy, Qingdao 266071, Shandong, China.
(4)Department of Clinical Laboratory, Weifang People's Hospital, Weifang 261000,
Shandong, China.
(5)Department of Military and Special Medicine, No.971 Hospital of The People's
Liberation Army Navy, Qingdao 266071, Shandong, China.
(6)Department of Military and Special Medicine, No.971 Hospital of The People's
Liberation Army Navy, Qingdao 266071, Shandong, China. Electronic address:
guangkaigao@gmail.com.
(7)Department of Special Medicine, School of Basic Medicine, Qingdao University,
Qingdao 266071, Shandong, China. Electronic address: xiayujun62@163.com.
Background Delayed encephalopathy (DE) is the most severe complication after
acute carbon monoxide (CO) poisoning, which seriously affects the outcome of
patients and leads to a high disability rate. Prior studies have shown that
hyperbaric oxygen (HBO2) therapy is therapeutic for DE due to reducing
immune-mediated neuropathology and thus improving cognitive performance. Methods
In our present perspective study, five DE patients were treated regularly with
HBO2 therapy. The mini-mental state examination (MMSE) and Barthel index (BI)
were intermittently collected during their hospitalization for mental and
physical status evaluation, the peripheral bloods were serially sampled to
determine the concentration changes of circulating stem cells, as well as
corresponding BDNF and neural markers. Results MMSE and BI showed series of
improvements after multiple HBO2 therapies. The CD34+/CD90+ and CD34+/CD133+
dual positive cells, which were categorized as circulating stem cells, were
observed an overall up-regulation since the beginning of the DE onset upon the
application of HBO2 therapy. Characteristic neurotrophin BDNF, neural markers
such as nestin and synaptophysin (SYP) were also up-regulated after exposure of
HBO2. Conclusion The application of HBO2 therapy is of significance in improving
the cognition of DE patients, along with mobilized circulating stem cells. We
primarily infer that the CD34+/CD90+ and CD34+/CD133+ cells were mobilized by
HBO2 exposure and have played a positive role in cognition improvement on DE
patients by up-regulation of BDNF, nestin and SYP. The altering amount of
circulating stem cells mobilized in peripheral blood could be a potential marker
on predicting the outcome of DE.
Copyright © 2021 Elsevier Inc. All rights reserved.
DOI: 10.1016/j.ajem.2021.01.021
PMID: 33497900 [Indexed for MEDLINE]
Conflict of interest statement: Declaration of competing interest We have no
competing interests to declare.
