Coelho GA, Secretan PH, Tortolano L, Charvet L, Yagoubi N, et al.
Journal of clinical medicine. Date of publication 2023 Aug 28;volume 12(17):.
1. J Clin Med. 2023 Aug 28;12(17):5605. doi: 10.3390/jcm12175605.
Evolution of the Chronic Venous Leg Ulcer Microenvironment and Its Impact on
Medical Devices and Wound Care Therapies.
Coelho GA(1)(2), Secretan PH(1), Tortolano L(1)(3), Charvet L(2), Yagoubi N(1).
Author information:
(1)Laboratoire Matériaux et Santé, Université Paris-Saclay, 91400 Orsay, France.
(2)Urgo Recherche Innovation et Développement, 21300 Chenove, France.
(3)Department of Pharmacy, Assistance Publique-Hôpitaux de Paris, Groupe
Hospitalier Henri Mondor, 94000 Créteil, France.
Studies have reported that the constituents of the wound microenvironment are
likely to have critical roles in the degradation and fate of the polymeric
matrix and the compounds dissolved in the wound dressing matrix. Thus, chronic
wound assessment and the design of effective medical devices and drug products
for wound care partly rely on an in-depth understanding of the wound
microenvironment. The main aim of this review is to identify and discuss the
different stages of chronic wound progression, focusing on the changes in the
biochemical composition of the wound microenvironment, with particular attention
given to venous leg ulcers (VLUs), as they are one of the most prevalent chronic
wound aetiologies. The pathophysiology of venous ulcers is detailed, followed by
a thorough review of what is known about the VLU microenvironment and its
changes as a function of the evolution of the VLU. Simulating conditions for VLU
are then discussed with the view of highlighting potentially relevant simulating
media as a function of VLU evolution for a better assessment of biological
safety, in particular medical devices intended to be in contact with these
wounds.
DOI: 10.3390/jcm12175605
PMCID: PMC10488485
PMID: 37685674
Conflict of interest statement: The authors declare no conflict of interest.
