Stoberock K, Kaschwich M, Nicolay SS, Mahmoud N, Heidemann F, Rieß HC, Debus ES, Behrendt CA, et al.
VASA. Zeitschrift fur Gefasskrankheiten. Date of publication 2021 Sep 1;volume 50(5):323-330.
1. Vasa. 2021 Sep;50(5):323-330. doi: 10.1024/0301-1526/a000925. Epub 2020 Nov
11.
The interrelationship between diabetes mellitus and peripheral arterial disease.
Stoberock K(1), Kaschwich M(1), Nicolay SS(1), Mahmoud N(1), Heidemann F(1),
Rieß HC(1), Debus ES(1), Behrendt CA(1).
Author information:
(1)Department of Vascular Medicine, Research Group GermanVasc, University
Medical Center Hamburg-Eppendorf, Hamburg, Germany.
This systematic review examined the interrelationship between concomitant
diabetes mellitus (DM) and peripheral arterial disease (PAD). The objective was
to determine differences in the prevalence as well as in the outcomes in
diabetic vs. non-diabetic PAD patients. The current review followed a study
protocol that was published online in German in 2017. The search included
societal practice guidelines, consensus statements, systematic reviews,
meta-analyses, and observational studies published from 2007 to 2020 reporting
symptomatic PAD and concomitant DM in patients undergoing invasive open-surgical
and endovascular revascularizations. German and English literature has been
considered. Eligibility criteria were verified by three independent reviewers.
Disagreement was resolved by discussion involving a fourth reviewer. 580
articles were identified. After exclusion of non-eligible studies, 61 papers
from 30 countries remained, respectively 850,072 patients. The included studies
showed that PAD prevalence differed between diabetic vs. non-diabetic
populations (20-50% vs. 10-26%), and further by age, gender, ethnicity, duration
of existing diabetes, and geographic region. The included studies revealed worse
outcomes regarding perioperative complications, amputation rate, and mortality
rate in diabetic patients when compared to non-diabetic patients. In both
groups, the amputation rates decreased during the research period. This review
emphasizes an interrelationship between PAD and DM. To improve the outcomes,
early detection of PAD in diabetic patients, and vice versa, should be
recommended. The results of this systematic review may help to update societal
practice guidelines.
DOI: 10.1024/0301-1526/a000925
PMID: 33175668 [Indexed for MEDLINE]
